Effectiveness of iNTS vaccination in sub-Saharan Africa
Abstract Invasive non-Typhoidal Salmonella (iNTS) is one of the leading causes of blood stream infections in Sub-Saharan Africa, especially among children. iNTS can be difficult to diagnose, particularly in areas where malaria is endemic, and difficult to treat, partly because of the emergence of an...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87659-4 |
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| author | Daniele Cassese Nicola Dimitri Gianluca Breghi Tiziana Spadafina |
| author_facet | Daniele Cassese Nicola Dimitri Gianluca Breghi Tiziana Spadafina |
| author_sort | Daniele Cassese |
| collection | DOAJ |
| description | Abstract Invasive non-Typhoidal Salmonella (iNTS) is one of the leading causes of blood stream infections in Sub-Saharan Africa, especially among children. iNTS can be difficult to diagnose, particularly in areas where malaria is endemic, and difficult to treat, partly because of the emergence of antibiotic resistance. We developed a mathematical model to evaluate the impact of a vaccine for iNTS in 49 countries of sub-Saharan Africa. Without vaccination we estimate 9.2 million new iNTS cases among children below 5 years old in these 49 countries from 2022 to 2038, 6.2 million of which between 2028 and 2038. The introduction of a $$85\%$$ ( $$95\%$$ ) efficacy vaccine in 2028 would prevent 2.6 (2.9) million of these new infections. We provide the country-specific impact of a iNTS vaccine considering the different age structures and vaccine coverage levels. |
| format | Article |
| id | doaj-art-2fbe3c8d27c746388c1e0ef4a71b0ab1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2fbe3c8d27c746388c1e0ef4a71b0ab12025-02-02T12:20:59ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-87659-4Effectiveness of iNTS vaccination in sub-Saharan AfricaDaniele Cassese0Nicola Dimitri1Gianluca Breghi2Tiziana Spadafina3Department of Economics, University of CambridgeDepartment of Economics, Universitá degli Studi di SienaFondazione Achille Sclavo ONLUSFondazione Achille Sclavo ONLUSAbstract Invasive non-Typhoidal Salmonella (iNTS) is one of the leading causes of blood stream infections in Sub-Saharan Africa, especially among children. iNTS can be difficult to diagnose, particularly in areas where malaria is endemic, and difficult to treat, partly because of the emergence of antibiotic resistance. We developed a mathematical model to evaluate the impact of a vaccine for iNTS in 49 countries of sub-Saharan Africa. Without vaccination we estimate 9.2 million new iNTS cases among children below 5 years old in these 49 countries from 2022 to 2038, 6.2 million of which between 2028 and 2038. The introduction of a $$85\%$$ ( $$95\%$$ ) efficacy vaccine in 2028 would prevent 2.6 (2.9) million of these new infections. We provide the country-specific impact of a iNTS vaccine considering the different age structures and vaccine coverage levels.https://doi.org/10.1038/s41598-025-87659-4iNTSModelVaccinationEffectivenessSub-Saharan Africa |
| spellingShingle | Daniele Cassese Nicola Dimitri Gianluca Breghi Tiziana Spadafina Effectiveness of iNTS vaccination in sub-Saharan Africa Scientific Reports iNTS Model Vaccination Effectiveness Sub-Saharan Africa |
| title | Effectiveness of iNTS vaccination in sub-Saharan Africa |
| title_full | Effectiveness of iNTS vaccination in sub-Saharan Africa |
| title_fullStr | Effectiveness of iNTS vaccination in sub-Saharan Africa |
| title_full_unstemmed | Effectiveness of iNTS vaccination in sub-Saharan Africa |
| title_short | Effectiveness of iNTS vaccination in sub-Saharan Africa |
| title_sort | effectiveness of ints vaccination in sub saharan africa |
| topic | iNTS Model Vaccination Effectiveness Sub-Saharan Africa |
| url | https://doi.org/10.1038/s41598-025-87659-4 |
| work_keys_str_mv | AT danielecassese effectivenessofintsvaccinationinsubsaharanafrica AT nicoladimitri effectivenessofintsvaccinationinsubsaharanafrica AT gianlucabreghi effectivenessofintsvaccinationinsubsaharanafrica AT tizianaspadafina effectivenessofintsvaccinationinsubsaharanafrica |