Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms. It is caused by an autoimmune response to self-antigens in a genetically...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/963748 |
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| author | Milan Buc |
| author_facet | Milan Buc |
| author_sort | Milan Buc |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms. It is caused by an autoimmune response to self-antigens in a genetically susceptible individual induced by unknown environmental factors. Principal cells of the immune system that drive the immunopathological processes are T cells, especially of TH1 and TH17 subsets. However, in recent years, it was disclosed that regulatory T cells took part in, too. Subsequently, there was endeavour to develop ways how to re-establish their physiological functions. In this review, we describe known mechanisms of action, efficacy, and side-effects of contemporary and emerging MS immunotherapeutical agents on Treg cells and other cells of the immune system involved in the immunopathogenesis of the disease. Furthermore, we discuss how laboratory immunology can offer physicians its help in the diagnosis process and decisions what kind of biological therapy should be used. |
| format | Article |
| id | doaj-art-2fb6869a455b41dbb9f45b659745dd42 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2fb6869a455b41dbb9f45b659745dd422025-02-03T01:30:14ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/963748963748Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple SclerosisMilan Buc0Department of Immunology, Comenius University School of Medicine, 813 72 Bratislava, SlovakiaMultiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms. It is caused by an autoimmune response to self-antigens in a genetically susceptible individual induced by unknown environmental factors. Principal cells of the immune system that drive the immunopathological processes are T cells, especially of TH1 and TH17 subsets. However, in recent years, it was disclosed that regulatory T cells took part in, too. Subsequently, there was endeavour to develop ways how to re-establish their physiological functions. In this review, we describe known mechanisms of action, efficacy, and side-effects of contemporary and emerging MS immunotherapeutical agents on Treg cells and other cells of the immune system involved in the immunopathogenesis of the disease. Furthermore, we discuss how laboratory immunology can offer physicians its help in the diagnosis process and decisions what kind of biological therapy should be used.http://dx.doi.org/10.1155/2013/963748 |
| spellingShingle | Milan Buc Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis Mediators of Inflammation |
| title | Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis |
| title_full | Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis |
| title_fullStr | Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis |
| title_full_unstemmed | Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis |
| title_short | Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis |
| title_sort | role of regulatory t cells in pathogenesis and biological therapy of multiple sclerosis |
| url | http://dx.doi.org/10.1155/2013/963748 |
| work_keys_str_mv | AT milanbuc roleofregulatorytcellsinpathogenesisandbiologicaltherapyofmultiplesclerosis |