Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running
Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus mus...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2010/870573 |
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| author | Andrea T. U. Schaefers Keren Grafen Gertraud Teuchert-Noodt York Winter |
| author_facet | Andrea T. U. Schaefers Keren Grafen Gertraud Teuchert-Noodt York Winter |
| author_sort | Andrea T. U. Schaefers |
| collection | DOAJ |
| description | Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). We examined synaptic turnover rates in the dentate gyrus, CA3, CA1, subiculum, and entorhinal cortex. No direct effects of deprived rearing on rates of synaptic turnover were found in any of the studied regions. However, adult wheel running had the effect of leveling layer-specific differences in synaptic remodeling in the dentate gyrus, CA3, and CA1, but not in the entorhinal cortex and subiculum of animals of both rearing treatments. Epigenetic effects during juvenile development affected adult neural plasticity in mice, but seemed to be less pronounced than in gerbils. |
| format | Article |
| id | doaj-art-2facfd1a747c4d66a4d2a165d013624d |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2facfd1a747c4d66a4d2a165d013624d2025-02-03T05:59:53ZengWileyNeural Plasticity2090-59041687-54432010-01-01201010.1155/2010/870573870573Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary RunningAndrea T. U. Schaefers0Keren Grafen1Gertraud Teuchert-Noodt2York Winter3Department of Biology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, GermanyDepartment of Biology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, GermanyDepartment of Biology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, GermanyDepartment of Biology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, GermanyHippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). We examined synaptic turnover rates in the dentate gyrus, CA3, CA1, subiculum, and entorhinal cortex. No direct effects of deprived rearing on rates of synaptic turnover were found in any of the studied regions. However, adult wheel running had the effect of leveling layer-specific differences in synaptic remodeling in the dentate gyrus, CA3, and CA1, but not in the entorhinal cortex and subiculum of animals of both rearing treatments. Epigenetic effects during juvenile development affected adult neural plasticity in mice, but seemed to be less pronounced than in gerbils.http://dx.doi.org/10.1155/2010/870573 |
| spellingShingle | Andrea T. U. Schaefers Keren Grafen Gertraud Teuchert-Noodt York Winter Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running Neural Plasticity |
| title | Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running |
| title_full | Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running |
| title_fullStr | Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running |
| title_full_unstemmed | Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running |
| title_short | Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running |
| title_sort | synaptic remodeling in the dentate gyrus ca3 ca1 subiculum and entorhinal cortex of mice effects of deprived rearing and voluntary running |
| url | http://dx.doi.org/10.1155/2010/870573 |
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