Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats
Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of...
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Plovdiv University Press
2025-01-01
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| Series: | Journal of BioScience and Biotechnology |
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| Online Access: | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/551/390 |
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| author | Ibrahim Abubakar Mu'azu Abubakar Gusau Jabir Aliyu Danyaya Shehu Ibrahim Zayyanu Abdullahi Abdulhakim Zubairu Abdulsalam Umar Sahabi |
| author_facet | Ibrahim Abubakar Mu'azu Abubakar Gusau Jabir Aliyu Danyaya Shehu Ibrahim Zayyanu Abdullahi Abdulhakim Zubairu Abdulsalam Umar Sahabi |
| author_sort | Ibrahim Abubakar |
| collection | DOAJ |
| description | Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of the ethylacetate fraction of methanol leaf extract of Hannoa klaineana in rats. The analgesic effect of the ethylacetate fraction of methanol leaves extract of Hannoa klaineana (200, 400, and 600 mg/kg b.wt) was evaluated using acetic acid-induced writhing, tail flick (immersion), and hot plate model. In the acetic acid-induced writhing test, the extract (200, 400, and 600 mg/kg) demonstrated a significant (p < 0.05) decrease in the number of writhes with maximum percentage inhibition (75.61%) at 600 mg/kg dose of the extract. In tail flick and hot plate tests, the extract (200, 400, and 600 mg/kg b.wt) exhibited a significant (p < 0.05) increase in rats’ response with a steady increase in reaction time. Findings from this study show that ethylacetate fraction of the methanol leaves extract of Hannoa klaineana possessed analgesic activity which provided justification for the local use of the plant in the treatment of pain. |
| format | Article |
| id | doaj-art-2fabafdbb5c640a98ddae7cd6debc3ff |
| institution | Kabale University |
| issn | 1314-6238 1314-6246 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Plovdiv University Press |
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| series | Journal of BioScience and Biotechnology |
| spelling | doaj-art-2fabafdbb5c640a98ddae7cd6debc3ff2025-01-28T07:39:37ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462025-01-0113215516110.69085/jbb20242155Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in ratsIbrahim Abubakar0Mu'azu Abubakar Gusau1Jabir Aliyu Danyaya2Shehu Ibrahim3Zayyanu Abdullahi4Abdulhakim Zubairu5Abdulsalam Umar Sahabi6Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University Sokoto, NigeriaDepartment of Biochemistry, Faculty of Science, Usmanu Danfodiyo University Sokoto, NigeriaBiochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, NigeriaDepartment of Chemistry, Shehu Shagari University of Education, Sokoto, NigeriaBiochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, NigeriaBiochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, NigeriaBiochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, NigeriaPain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of the ethylacetate fraction of methanol leaf extract of Hannoa klaineana in rats. The analgesic effect of the ethylacetate fraction of methanol leaves extract of Hannoa klaineana (200, 400, and 600 mg/kg b.wt) was evaluated using acetic acid-induced writhing, tail flick (immersion), and hot plate model. In the acetic acid-induced writhing test, the extract (200, 400, and 600 mg/kg) demonstrated a significant (p < 0.05) decrease in the number of writhes with maximum percentage inhibition (75.61%) at 600 mg/kg dose of the extract. In tail flick and hot plate tests, the extract (200, 400, and 600 mg/kg b.wt) exhibited a significant (p < 0.05) increase in rats’ response with a steady increase in reaction time. Findings from this study show that ethylacetate fraction of the methanol leaves extract of Hannoa klaineana possessed analgesic activity which provided justification for the local use of the plant in the treatment of pain.https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/551/390acetic acidanalgesicsdiclofenachannoa klaineanapain |
| spellingShingle | Ibrahim Abubakar Mu'azu Abubakar Gusau Jabir Aliyu Danyaya Shehu Ibrahim Zayyanu Abdullahi Abdulhakim Zubairu Abdulsalam Umar Sahabi Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats Journal of BioScience and Biotechnology acetic acid analgesics diclofenac hannoa klaineana pain |
| title | Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats |
| title_full | Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats |
| title_fullStr | Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats |
| title_full_unstemmed | Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats |
| title_short | Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats |
| title_sort | analgesic effect of ethylacetate fraction of the methanol leaves extract of hannoa klaineana in rats |
| topic | acetic acid analgesics diclofenac hannoa klaineana pain |
| url | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/551/390 |
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