Elevated Vulnerability of Chronic Leukemia Patients to COVID.19 Infection: A Systems Biology Approach
Background Emerging evidence has shown that SARS-CoV-2 may affect the circulatory system in addition to the human respiratory system. However, no study has indicated whether patients with leukemia have a greater likelihood of SARSCoV-2 infection or have poor treatment outcomes. Objective The study a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Dr. Sulaiman Al Habib Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.1007/s44229-022-00005-y |
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| Summary: | Background
Emerging evidence has shown that SARS-CoV-2 may affect the circulatory system in addition to the human respiratory system. However, no study has indicated whether patients with leukemia have a greater likelihood of SARSCoV-2 infection or have poor treatment outcomes.
Objective
The study aimed to demonstrate the relationship between essential blood proteins and the major SARS-CoV-2 proteins by network pharmacology bioinformatics analysis.
Methods
Bioinformatics analysis was used to establish eight differentially expressed gene hubs in leukemia through differential gene screening, protein, protein interaction network analysis, and gene enrichment analysis. Molecular docking analysis was also conducted to dock the two up-regulated proteins with the spike glycoprotein in leukemia and the critical protease enzyme (Mpro) of SARS-CoV-2.
Results
We identified two up-regulated genes (PTPRC and BCL6) among the eight differentially expressed genes. The PTPRC and BCL6 also docked perfectly with the main SARS-CoV-2 structural proteins.
Conclusion and Recommendation
This study indicates that SARS-CoV-2 is likely to affect with the blood in patients with chronic leukemia. Therefore, patients with chronic leukemia require greater medical attention and precautions during the COVID-19 pandemic. |
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| ISSN: | 2666-819X 2590-3349 |