Persistent NK cell deficiency associated with pulmonary cryptococcosis

Persistent NK cell deficiency associated with pulmonary cryptococcosis

Abstract We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case...

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Bibliographic Details
Main Authors: Martin Martinot, Shu Shun Li, Catherine Farnarier, Cléa Dubrou, Christelle Piperoglou, Christopher H. Mody, Frederic Vely
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
NK cells
NK cell deficiency
Cryptococcus
CD8 clonotype
Vβ14 repertoire
Online Access:https://doi.org/10.1186/s12941-024-00771-7
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