Persistent NK cell deficiency associated with pulmonary cryptococcosis
Abstract We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12941-024-00771-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594890070949888 |
|---|---|
| author | Martin Martinot Shu Shun Li Catherine Farnarier Cléa Dubrou Christelle Piperoglou Christopher H. Mody Frederic Vely |
| author_facet | Martin Martinot Shu Shun Li Catherine Farnarier Cléa Dubrou Christelle Piperoglou Christopher H. Mody Frederic Vely |
| author_sort | Martin Martinot |
| collection | DOAJ |
| description | Abstract We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus. |
| format | Article |
| id | doaj-art-2f95ba0de86e447e8b2390915497d54e |
| institution | Kabale University |
| issn | 1476-0711 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj-art-2f95ba0de86e447e8b2390915497d54e2025-01-19T12:13:27ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112025-01-012411510.1186/s12941-024-00771-7Persistent NK cell deficiency associated with pulmonary cryptococcosisMartin Martinot0Shu Shun Li1Catherine Farnarier2Cléa Dubrou3Christelle Piperoglou4Christopher H. Mody5Frederic Vely6Infectious Diseases Department, Hôpitaux Civils de ColmarDepartment of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of CalgaryMarseille University Hospital Timone, Public Assistance Marseille HospitalsMarseille University Hospital Timone, Public Assistance Marseille HospitalsMarseille University Hospital Timone, Public Assistance Marseille HospitalsDepartment of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of CalgaryMarseille University Hospital Timone, Public Assistance Marseille HospitalsAbstract We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.https://doi.org/10.1186/s12941-024-00771-7NK cellsNK cell deficiencyCryptococcusCD8 clonotypeVβ14 repertoire |
| spellingShingle | Martin Martinot Shu Shun Li Catherine Farnarier Cléa Dubrou Christelle Piperoglou Christopher H. Mody Frederic Vely Persistent NK cell deficiency associated with pulmonary cryptococcosis Annals of Clinical Microbiology and Antimicrobials NK cells NK cell deficiency Cryptococcus CD8 clonotype Vβ14 repertoire |
| title | Persistent NK cell deficiency associated with pulmonary cryptococcosis |
| title_full | Persistent NK cell deficiency associated with pulmonary cryptococcosis |
| title_fullStr | Persistent NK cell deficiency associated with pulmonary cryptococcosis |
| title_full_unstemmed | Persistent NK cell deficiency associated with pulmonary cryptococcosis |
| title_short | Persistent NK cell deficiency associated with pulmonary cryptococcosis |
| title_sort | persistent nk cell deficiency associated with pulmonary cryptococcosis |
| topic | NK cells NK cell deficiency Cryptococcus CD8 clonotype Vβ14 repertoire |
| url | https://doi.org/10.1186/s12941-024-00771-7 |
| work_keys_str_mv | AT martinmartinot persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT shushunli persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT catherinefarnarier persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT cleadubrou persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT christellepiperoglou persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT christopherhmody persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis AT fredericvely persistentnkcelldeficiencyassociatedwithpulmonarycryptococcosis |