Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats
The effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoida...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0006 |
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| author | Dimitrova Darinka Getova Damianka Saracheva Kremena |
| author_facet | Dimitrova Darinka Getova Damianka Saracheva Kremena |
| author_sort | Dimitrova Darinka |
| collection | DOAJ |
| description | The effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoidance tests (step-through and step-down) were performed according to the experimental design. There were 10 groups of rats (n = 8) and the substances studied were applied orally before each testing session. In the active avoidance test, the number of conditioned stimuli (avoidances), unconditioned stimuli (escapes) and intertrial crossings were observed. In step-down and step-through passive avoidance tests, the latencies of reactions were observed. All the studied compounds showed positive effects in the learning and memory tests, compared to the controls. It was concluded that HEAPO, donepezil and galantamine had a memory-enhancing effect in active and passive avoidance tests. |
| format | Article |
| id | doaj-art-2f85771c2cc240e89086944c926b2aa2 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2f85771c2cc240e89086944c926b2aa22025-02-02T14:50:11ZengSciendoActa Pharmaceutica1846-95582023-03-017319110510.2478/acph-2023-0006Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar ratsDimitrova Darinka0Getova Damianka1Saracheva Kremena2Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University-PlovdivBulgariaNational Scientific Fund, Expert Committee of Medical Sciences, Sofia BulgariaDepartment of Pharmacology, Toxicology and Pharmacotherapy Faculty of Pharmacy, Medical University-Plovdiv, BulgariaThe effects of 3R,16S-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoidance tests (step-through and step-down) were performed according to the experimental design. There were 10 groups of rats (n = 8) and the substances studied were applied orally before each testing session. In the active avoidance test, the number of conditioned stimuli (avoidances), unconditioned stimuli (escapes) and intertrial crossings were observed. In step-down and step-through passive avoidance tests, the latencies of reactions were observed. All the studied compounds showed positive effects in the learning and memory tests, compared to the controls. It was concluded that HEAPO, donepezil and galantamine had a memory-enhancing effect in active and passive avoidance tests.https://doi.org/10.2478/acph-2023-0006vinpocetine derivatives3r, 16s-2-hydroxyethyl apovincaminate (heapo)donepezilgalantaminememory testsrats |
| spellingShingle | Dimitrova Darinka Getova Damianka Saracheva Kremena Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats Acta Pharmaceutica vinpocetine derivatives 3r, 16s-2-hydroxyethyl apovincaminate (heapo) donepezil galantamine memory tests rats |
| title | Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats |
| title_full | Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats |
| title_fullStr | Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats |
| title_full_unstemmed | Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats |
| title_short | Effects of 3R, 16S-2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats |
| title_sort | effects of 3r 16s 2 hydroxyethyl apovincaminate heapo donepezil and galantamine on learning and memory retention in naive wistar rats |
| topic | vinpocetine derivatives 3r, 16s-2-hydroxyethyl apovincaminate (heapo) donepezil galantamine memory tests rats |
| url | https://doi.org/10.2478/acph-2023-0006 |
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