A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation
Exercise-related intermittent claudication is marked by reduced blood flow to extremities caused by either stenosis or impaired vascular function. Although intermittent claudication is common in the elderly, it rarely occurs in the young and middle-aged individuals. Here, we report a case of exercis...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/4868123 |
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| author | J. J. Posthuma K. D. Reesink M. Schütten C. Ghossein M. E. Spaanderman H. ten Cate G. Schep |
| author_facet | J. J. Posthuma K. D. Reesink M. Schütten C. Ghossein M. E. Spaanderman H. ten Cate G. Schep |
| author_sort | J. J. Posthuma |
| collection | DOAJ |
| description | Exercise-related intermittent claudication is marked by reduced blood flow to extremities caused by either stenosis or impaired vascular function. Although intermittent claudication is common in the elderly, it rarely occurs in the young and middle-aged individuals. Here, we report a case of exercise-related claudication in a 41-year-old woman, in the absence of overt vascular pathology. Using a series of imaging and functional tests, we established that her complaints were due to impaired arterial vasodilation, possibly due to a defect in nitrous oxide-mediated dilation. The symptoms were reversible upon administration of a calcium antagonist, showing reversibility of the vascular impairment. Identification of reversible vascular “stiffness” merits consideration in young and otherwise healthy subjects with claudication of unknown origin. |
| format | Article |
| id | doaj-art-2f69b41e6b83478b8fa01d67f40eb090 |
| institution | Kabale University |
| issn | 2090-6986 2090-6994 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Vascular Medicine |
| spelling | doaj-art-2f69b41e6b83478b8fa01d67f40eb0902025-02-03T07:25:29ZengWileyCase Reports in Vascular Medicine2090-69862090-69942017-01-01201710.1155/2017/48681234868123A Rare Case of Intermittent Claudication Associated with Impaired Arterial VasodilationJ. J. Posthuma0K. D. Reesink1M. Schütten2C. Ghossein3M. E. Spaanderman4H. ten Cate5G. Schep6Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Biomedical Engineering, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, NetherlandsLaboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Sports Medicine, Máxima Medical Centre, Veldhoven, NetherlandsExercise-related intermittent claudication is marked by reduced blood flow to extremities caused by either stenosis or impaired vascular function. Although intermittent claudication is common in the elderly, it rarely occurs in the young and middle-aged individuals. Here, we report a case of exercise-related claudication in a 41-year-old woman, in the absence of overt vascular pathology. Using a series of imaging and functional tests, we established that her complaints were due to impaired arterial vasodilation, possibly due to a defect in nitrous oxide-mediated dilation. The symptoms were reversible upon administration of a calcium antagonist, showing reversibility of the vascular impairment. Identification of reversible vascular “stiffness” merits consideration in young and otherwise healthy subjects with claudication of unknown origin.http://dx.doi.org/10.1155/2017/4868123 |
| spellingShingle | J. J. Posthuma K. D. Reesink M. Schütten C. Ghossein M. E. Spaanderman H. ten Cate G. Schep A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation Case Reports in Vascular Medicine |
| title | A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation |
| title_full | A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation |
| title_fullStr | A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation |
| title_full_unstemmed | A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation |
| title_short | A Rare Case of Intermittent Claudication Associated with Impaired Arterial Vasodilation |
| title_sort | rare case of intermittent claudication associated with impaired arterial vasodilation |
| url | http://dx.doi.org/10.1155/2017/4868123 |
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