Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy
Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus. New therapeutic strategies are needed to prevent the onset of diabeti...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/879523 |
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| _version_ | 1832560934029099008 |
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| author | Shinji Kume Takashi Uzu Keiji Isshiki Daisuke Koya |
| author_facet | Shinji Kume Takashi Uzu Keiji Isshiki Daisuke Koya |
| author_sort | Shinji Kume |
| collection | DOAJ |
| description | Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus. New therapeutic strategies are needed to prevent the onset of diabetic nephropathy. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases. These agents might prevent the progression of diabetic nephropathy, since PPAR agonists improve dyslipidemia and insulin resistance. Furthermore, data from murine models suggest that PPAR agonists also have independent renoprotective effects by suppressing inflammation, oxidative stress, lipotoxicity, and activation of the renin-angiotensin system. This review summarizes data from clinical and experimental studies regarding the relationship between PPARs and diabetic nephropathy. The therapeutic potential of PPAR agonists in the treatment of diabetic nephropathy is also discussed. |
| format | Article |
| id | doaj-art-2f655aa92b984cbda787c375ff1b9b37 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-2f655aa92b984cbda787c375ff1b9b372025-02-03T01:26:21ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/879523879523Peroxisome Proliferator-Activated Receptors in Diabetic NephropathyShinji Kume0Takashi Uzu1Keiji Isshiki2Daisuke Koya3Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, JapanDepartment of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, JapanDepartment of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, JapanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kanazawa Medical University, Ishikawa 920-0293, JapanDiabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus. New therapeutic strategies are needed to prevent the onset of diabetic nephropathy. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases. These agents might prevent the progression of diabetic nephropathy, since PPAR agonists improve dyslipidemia and insulin resistance. Furthermore, data from murine models suggest that PPAR agonists also have independent renoprotective effects by suppressing inflammation, oxidative stress, lipotoxicity, and activation of the renin-angiotensin system. This review summarizes data from clinical and experimental studies regarding the relationship between PPARs and diabetic nephropathy. The therapeutic potential of PPAR agonists in the treatment of diabetic nephropathy is also discussed.http://dx.doi.org/10.1155/2008/879523 |
| spellingShingle | Shinji Kume Takashi Uzu Keiji Isshiki Daisuke Koya Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy PPAR Research |
| title | Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy |
| title_full | Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy |
| title_fullStr | Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy |
| title_short | Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy |
| title_sort | peroxisome proliferator activated receptors in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2008/879523 |
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