Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I
Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient wit...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600589522 |
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| author | Yukitoshi Takahashi Kazumi Matsuda Yuko Kubota Jiro Shimomura Etsuko Yamasaki Tatsuya Kudo Katsuyuki Fukushima Hitoshi Osaka Noriyuki Akasaka Atsushi Imamura Shinji Yamada Naomi Kondo Tateki Fujiwara |
| author_facet | Yukitoshi Takahashi Kazumi Matsuda Yuko Kubota Jiro Shimomura Etsuko Yamasaki Tatsuya Kudo Katsuyuki Fukushima Hitoshi Osaka Noriyuki Akasaka Atsushi Imamura Shinji Yamada Naomi Kondo Tateki Fujiwara |
| author_sort | Yukitoshi Takahashi |
| collection | DOAJ |
| description | Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). The relative risks of HLA class I genotypes for Rasmussen syndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). The relative risks of HLA class I-A and B haplotypes are infinity (A*2601+B*5401), 21.1 (A*2402+B*1501), 13.3 (A*2402+B*4801) and 5.1 (A*2402+B*5201). Some alleles and haplotypes of HLA class I may be the risk factors in Japanese patients. Cross-reactivity of cytotoxic T lymphocytes may contribute to the processes leading from infection to the involvement of CNS. |
| format | Article |
| id | doaj-art-2f63fddd634c494598c9f5429b51d1de |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2f63fddd634c494598c9f5429b51d1de2025-02-03T06:14:02ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01132-438138710.1080/17402520600589522Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class IYukitoshi Takahashi0Kazumi Matsuda1Yuko Kubota2Jiro Shimomura3Etsuko Yamasaki4Tatsuya Kudo5Katsuyuki Fukushima6Hitoshi Osaka7Noriyuki Akasaka8Atsushi Imamura9Shinji Yamada10Naomi Kondo11Tateki Fujiwara12National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanKanagawa Children's Medical Center, Mutsukawa 2-138-4, Minami-ku, Yokohama 232-8555, JapanNational Nishi-Niigata Central Hospital, 1-14-1 Masago, Niigata 950-2085, JapanGifu Prefectural Gifu Hospital, 4-6-1 Noishiki, Gifu, 500-8717, JapanChunou Kosei Hospital, 5-1 Wakakusa-dori, Seki 501-3802, JapanDepartment of Pediatrics, Gifu University School of Medicine, Gifu 500-8705, JapanNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-868, JapanRasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). The relative risks of HLA class I genotypes for Rasmussen syndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). The relative risks of HLA class I-A and B haplotypes are infinity (A*2601+B*5401), 21.1 (A*2402+B*1501), 13.3 (A*2402+B*4801) and 5.1 (A*2402+B*5201). Some alleles and haplotypes of HLA class I may be the risk factors in Japanese patients. Cross-reactivity of cytotoxic T lymphocytes may contribute to the processes leading from infection to the involvement of CNS.http://dx.doi.org/10.1080/17402520600589522 |
| spellingShingle | Yukitoshi Takahashi Kazumi Matsuda Yuko Kubota Jiro Shimomura Etsuko Yamasaki Tatsuya Kudo Katsuyuki Fukushima Hitoshi Osaka Noriyuki Akasaka Atsushi Imamura Shinji Yamada Naomi Kondo Tateki Fujiwara Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I Clinical and Developmental Immunology |
| title | Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I |
| title_full | Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I |
| title_fullStr | Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I |
| title_full_unstemmed | Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I |
| title_short | Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I |
| title_sort | vaccination and infection as causative factors in japanese patients with rasmussen syndrome molecular mimicry and hla class i |
| url | http://dx.doi.org/10.1080/17402520600589522 |
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