Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)

Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)

Introduction: The PI3K/AKT/mTOR signaling pathway plays a significant role in the development of T-cell acute lymphoblastic leukemia (T-ALL). Rapamycin is a potential therapeutic strategy for hematological malignancies due to its ability to suppress mTOR activity. Additionally, microRNAs (miRNAs) ha...

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Bibliographic Details
Main Authors: Fateme Arjmand, Samaneh Shojaei, Mitra Khalili, Hossein Dinmohammadi, Behzad Poopak, Samira Mohammadi-Yeganeh, Yousef Mortazavi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-07-01
Series:BioImpacts
Subjects:
mirna
pi3k/akt/mtor
mir-3143
mir-3182
t-cell acute lymphoblastic leukemia
rapamycin
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-14-28870.pdf
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