Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers
<i>Background and Objectives</i>: Bone and mineral disease (BMD) is a prevalent complication of advanced chronic kidney disease (CKD). The risk of fractures can be assessed via dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). This study aims to evaluate...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/1/152 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587980457377792 |
|---|---|
| author | Aydan Mutis Alan Zehra Sezer Ahmet Oz Cebrail Karaca Mevlüt Tamer Dinçer Ahmet Murt Fatma Beyza Sag Selma Alagoz Serdar Sahin Mustafa Sait Gonen Elif Güzel Sinan Trabulus Nurhan Seyahi |
| author_facet | Aydan Mutis Alan Zehra Sezer Ahmet Oz Cebrail Karaca Mevlüt Tamer Dinçer Ahmet Murt Fatma Beyza Sag Selma Alagoz Serdar Sahin Mustafa Sait Gonen Elif Güzel Sinan Trabulus Nurhan Seyahi |
| author_sort | Aydan Mutis Alan |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Bone and mineral disease (BMD) is a prevalent complication of advanced chronic kidney disease (CKD). The risk of fractures can be assessed via dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). This study aims to evaluate the effectiveness of two imaging modalities in identifying bone mineral status in individuals with pre-dialysis chronic renal disease and to assess their correlation with bone turnover markers. <i>Materials and Methods</i>: This controlled cross-sectional study, conducted at a single center from 2019 to 2022, assessed two groups of individuals aged 18 to 50. The patient cohort consisted of individuals with stage 4–5 chronic kidney disease, whereas the control cohort consisted of healthy participants. The participants’ bone and mineral status was evaluated using both QCT and DXA methods. Diagnostic measurements of the lumbar spine and femoral neck, obtained using DXA and QCT, were compared. Z-scores were utilized to evaluate low bone mineral density, with low Z-scores identified in either lumbar spine or femoral neck measures being seen as indicative of low bone mineral density. <i>Results</i>: Data from 38 participants (patient group: 18; control group: 20) who underwent QCT and/or DXA were evaluated. Thirty-three subjects were assessed using both QCT and DXA (patient group: 14; control group: 19). The median age of the patient cohort was 44 (range: 22–50), whereas the median age of the control cohort was 42 (range: 27–48) (<i>p</i> = 0.72). Women constituted 33% of the patient cohort and 50% of the control cohort (<i>p</i> = 0.23). In the patient cohort, low bone mineral density was detected in four individuals (28%) through QCT, and in just two patients (14%) through DXA. Compared to DXA, QCT identified a higher number of cases of low bone mineral density in the CKD cohort; however, no statistically significant difference was observed (<i>p</i> = 0.06). In addition, our study found that TRACP5b had a strong negative correlation with the DXA L1–L4 Z-score. <i>Conclusions</i>: This study revealed that QCT may be more sensitive than DXA for detecting low bone density in pre-dialysis CKD patients. Additionally, DXA may overestimate lumbar spine BMD in this population, and the strong negative correlation between TRACP5b levels and the DXA L1–L4 Z-score highlights the potential role of biochemical markers in assessing bone status in CKD |
| format | Article |
| id | doaj-art-2f55aa777ca3470787a8a2895c07fb95 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-2f55aa777ca3470787a8a2895c07fb952025-01-24T13:40:52ZengMDPI AGMedicina1010-660X1648-91442025-01-0161115210.3390/medicina61010152Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover MarkersAydan Mutis Alan0Zehra Sezer1Ahmet Oz2Cebrail Karaca3Mevlüt Tamer Dinçer4Ahmet Murt5Fatma Beyza Sag6Selma Alagoz7Serdar Sahin8Mustafa Sait Gonen9Elif Güzel10Sinan Trabulus11Nurhan Seyahi12Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, TurkeyDepartment of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDepartment of Radiology, Cerrahpsa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, TurkeyDepartment of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul 34200, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDepartment of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, TurkeyDivision of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34098, Turkey<i>Background and Objectives</i>: Bone and mineral disease (BMD) is a prevalent complication of advanced chronic kidney disease (CKD). The risk of fractures can be assessed via dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). This study aims to evaluate the effectiveness of two imaging modalities in identifying bone mineral status in individuals with pre-dialysis chronic renal disease and to assess their correlation with bone turnover markers. <i>Materials and Methods</i>: This controlled cross-sectional study, conducted at a single center from 2019 to 2022, assessed two groups of individuals aged 18 to 50. The patient cohort consisted of individuals with stage 4–5 chronic kidney disease, whereas the control cohort consisted of healthy participants. The participants’ bone and mineral status was evaluated using both QCT and DXA methods. Diagnostic measurements of the lumbar spine and femoral neck, obtained using DXA and QCT, were compared. Z-scores were utilized to evaluate low bone mineral density, with low Z-scores identified in either lumbar spine or femoral neck measures being seen as indicative of low bone mineral density. <i>Results</i>: Data from 38 participants (patient group: 18; control group: 20) who underwent QCT and/or DXA were evaluated. Thirty-three subjects were assessed using both QCT and DXA (patient group: 14; control group: 19). The median age of the patient cohort was 44 (range: 22–50), whereas the median age of the control cohort was 42 (range: 27–48) (<i>p</i> = 0.72). Women constituted 33% of the patient cohort and 50% of the control cohort (<i>p</i> = 0.23). In the patient cohort, low bone mineral density was detected in four individuals (28%) through QCT, and in just two patients (14%) through DXA. Compared to DXA, QCT identified a higher number of cases of low bone mineral density in the CKD cohort; however, no statistically significant difference was observed (<i>p</i> = 0.06). In addition, our study found that TRACP5b had a strong negative correlation with the DXA L1–L4 Z-score. <i>Conclusions</i>: This study revealed that QCT may be more sensitive than DXA for detecting low bone density in pre-dialysis CKD patients. Additionally, DXA may overestimate lumbar spine BMD in this population, and the strong negative correlation between TRACP5b levels and the DXA L1–L4 Z-score highlights the potential role of biochemical markers in assessing bone status in CKDhttps://www.mdpi.com/1648-9144/61/1/152dual-energy absorptiometryquantitative computed tomographybone turnover markerschronic kidney diseasebone mineral density |
| spellingShingle | Aydan Mutis Alan Zehra Sezer Ahmet Oz Cebrail Karaca Mevlüt Tamer Dinçer Ahmet Murt Fatma Beyza Sag Selma Alagoz Serdar Sahin Mustafa Sait Gonen Elif Güzel Sinan Trabulus Nurhan Seyahi Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers Medicina dual-energy absorptiometry quantitative computed tomography bone turnover markers chronic kidney disease bone mineral density |
| title | Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers |
| title_full | Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers |
| title_fullStr | Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers |
| title_full_unstemmed | Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers |
| title_short | Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Markers |
| title_sort | evaluation of bone mineral metabolism in pre dialysis chronic kidney disease quantitative computed tomography vs dual energy absorptiometry and correlation with bone turnover markers |
| topic | dual-energy absorptiometry quantitative computed tomography bone turnover markers chronic kidney disease bone mineral density |
| url | https://www.mdpi.com/1648-9144/61/1/152 |
| work_keys_str_mv | AT aydanmutisalan evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT zehrasezer evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT ahmetoz evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT cebrailkaraca evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT mevluttamerdincer evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT ahmetmurt evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT fatmabeyzasag evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT selmaalagoz evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT serdarsahin evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT mustafasaitgonen evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT elifguzel evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT sinantrabulus evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers AT nurhanseyahi evaluationofbonemineralmetabolisminpredialysischronickidneydiseasequantitativecomputedtomographyvsdualenergyabsorptiometryandcorrelationwithboneturnovermarkers |