Alterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation

Alterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation

Abstract Sleep fragmentation (SF) is increasingly recognized as a contributing factor to postoperative cognitive dysfunction (POCD). Given the critical roles of somatostatin (SST) interneurons, associated gamma‐aminobutyric acid (GABA)ergic neurotransmitters, and hippocampal perfusion in sleep‐relat...

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Bibliographic Details
Main Authors: Yun Li, Jiafeng Yu, Ningzhi Yang, Siwen Long, Yize Li, Lina Zhao, Yonghao Yu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Physiological Reports
Subjects:
aging
hippocampus
magnetic resonance imaging
POCD
sleep fragmentation
somatostatin
Online Access:https://doi.org/10.14814/phy2.70153
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