Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease
Pain was rarely studied in Huntington’s disease (HD). We presently aimed to extend our previous study on pain pathways functions by laser evoked potentials (LEPs) to a larger cohort of early unmedicated HD patients and a small group of presymptomatic HD (PHD) subjects. Forty-two early HD patients, 1...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2016/8613729 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554957451034624 |
|---|---|
| author | Marina de Tommaso Giovanni Franco Katia Ricci Anna Montemurno Vittorio Sciruicchio |
| author_facet | Marina de Tommaso Giovanni Franco Katia Ricci Anna Montemurno Vittorio Sciruicchio |
| author_sort | Marina de Tommaso |
| collection | DOAJ |
| description | Pain was rarely studied in Huntington’s disease (HD). We presently aimed to extend our previous study on pain pathways functions by laser evoked potentials (LEPs) to a larger cohort of early unmedicated HD patients and a small group of presymptomatic HD (PHD) subjects. Forty-two early HD patients, 10 PHD patients, and 64 controls were submitted to LEPs by right-hand stimulation. Two series of 30 laser stimuli were delivered, and artifact-free responses were averaged. The N1, N2, and P2 latencies were significantly increased and the N2P2 amplitude significantly reduced in HD patients compared to controls. In the HD group, the LEPs abnormalities correlated with functional decline. PHD subjects showed a slight and insignificant increase in LEPs latencies, which was inversely correlated with the possible age of HD clinical onset. Data of the present study seem to suggest that the functional state of nociceptive pathways as assessed by LEPs may be a potential biomarker of disease onset and progression. The assessment of pain symptoms in premanifest and manifest HD may also open a new scenario in terms of subtle disturbances of pain processing, which may have a role in the global burden of the disease. |
| format | Article |
| id | doaj-art-2f4c565af8d84106b7fcb8c7da44201e |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-2f4c565af8d84106b7fcb8c7da44201e2025-02-03T05:49:56ZengWileyBehavioural Neurology0953-41801875-85842016-01-01201610.1155/2016/86137298613729Laser Evoked Potentials in Early and Presymptomatic Huntington’s DiseaseMarina de Tommaso0Giovanni Franco1Katia Ricci2Anna Montemurno3Vittorio Sciruicchio4Apulian Referral Center for Huntington’s Disease, Basic Medical Sciences, Neuroscience and Sensory System Department (SMBNOS), University of Bari Aldo Moro, ItalyApulian Referral Center for Huntington’s Disease, Basic Medical Sciences, Neuroscience and Sensory System Department (SMBNOS), University of Bari Aldo Moro, ItalyApulian Referral Center for Huntington’s Disease, Basic Medical Sciences, Neuroscience and Sensory System Department (SMBNOS), University of Bari Aldo Moro, ItalyApulian Referral Center for Huntington’s Disease, Basic Medical Sciences, Neuroscience and Sensory System Department (SMBNOS), University of Bari Aldo Moro, ItalyApulian Referral Center for Huntington’s Disease, Basic Medical Sciences, Neuroscience and Sensory System Department (SMBNOS), University of Bari Aldo Moro, ItalyPain was rarely studied in Huntington’s disease (HD). We presently aimed to extend our previous study on pain pathways functions by laser evoked potentials (LEPs) to a larger cohort of early unmedicated HD patients and a small group of presymptomatic HD (PHD) subjects. Forty-two early HD patients, 10 PHD patients, and 64 controls were submitted to LEPs by right-hand stimulation. Two series of 30 laser stimuli were delivered, and artifact-free responses were averaged. The N1, N2, and P2 latencies were significantly increased and the N2P2 amplitude significantly reduced in HD patients compared to controls. In the HD group, the LEPs abnormalities correlated with functional decline. PHD subjects showed a slight and insignificant increase in LEPs latencies, which was inversely correlated with the possible age of HD clinical onset. Data of the present study seem to suggest that the functional state of nociceptive pathways as assessed by LEPs may be a potential biomarker of disease onset and progression. The assessment of pain symptoms in premanifest and manifest HD may also open a new scenario in terms of subtle disturbances of pain processing, which may have a role in the global burden of the disease.http://dx.doi.org/10.1155/2016/8613729 |
| spellingShingle | Marina de Tommaso Giovanni Franco Katia Ricci Anna Montemurno Vittorio Sciruicchio Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease Behavioural Neurology |
| title | Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease |
| title_full | Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease |
| title_fullStr | Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease |
| title_full_unstemmed | Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease |
| title_short | Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease |
| title_sort | laser evoked potentials in early and presymptomatic huntington s disease |
| url | http://dx.doi.org/10.1155/2016/8613729 |
| work_keys_str_mv | AT marinadetommaso laserevokedpotentialsinearlyandpresymptomatichuntingtonsdisease AT giovannifranco laserevokedpotentialsinearlyandpresymptomatichuntingtonsdisease AT katiaricci laserevokedpotentialsinearlyandpresymptomatichuntingtonsdisease AT annamontemurno laserevokedpotentialsinearlyandpresymptomatichuntingtonsdisease AT vittoriosciruicchio laserevokedpotentialsinearlyandpresymptomatichuntingtonsdisease |