Boosting anti-tumor immunity with TILT-517 oncolytic adenovirus and checkpoint blockade in renal cell carcinoma

Boosting anti-tumor immunity with TILT-517 oncolytic adenovirus and checkpoint blockade in renal cell carcinoma

Elevated levels of immune infiltration found in renal cell carcinoma are often associated with poor patient prognosis, likely due to T cell exhaustion and an immunosuppressive tumor microenvironment, which limits the efficacy of current immunotherapies. In this study, we focused on the use of Ad5/3-...

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Bibliographic Details
Main Authors: Victor Arias, Tatiana V. Kudling, James H.A. Clubb, Elise Jirovec, Santeri A. Pakola, Mirte Van der Heijden, Saru Basnet, Dafne C.A. Quixabeira, Lyna Haybout, Nea Ojala, Susanna Grönberg-Vähä-Koskela, Anna Kanerva, Antti Rannikko, João M. Santos, Victor Cervera-Carrascon, Otto Hemminki, Akseli Hemminki
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: regular issue
oncolytic virus
adenovirus
immunotherapy
T cell exhaustion
interleukin 7
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000487
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