Spindle Activity Orchestrates Plasticity during Development and Sleep
Spindle oscillations have been described during early brain development and in the adult brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle bursts (NSBs) and adult sleep spindles (ASSs) show differences in their occurrence, spatial distribution, and underlyin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/5787423 |
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| _version_ | 1832545491375620096 |
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| author | Christoph Lindemann Joachim Ahlbeck Sebastian H. Bitzenhofer Ileana L. Hanganu-Opatz |
| author_facet | Christoph Lindemann Joachim Ahlbeck Sebastian H. Bitzenhofer Ileana L. Hanganu-Opatz |
| author_sort | Christoph Lindemann |
| collection | DOAJ |
| description | Spindle oscillations have been described during early brain development and in the adult brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle bursts (NSBs) and adult sleep spindles (ASSs) show differences in their occurrence, spatial distribution, and underlying mechanisms. While NSBs have been proposed to coordinate the refinement of the maturating neuronal network, ASSs are associated with the implementation of acquired information within existing networks. Along with these functional differences, separate synaptic plasticity mechanisms seem to be recruited. Here, we review the generation of spindle oscillations in the developing and adult brain and discuss possible implications of their differences for synaptic plasticity. The first part of the review is dedicated to the generation and function of ASSs with a particular focus on their role in healthy and impaired neuronal networks. The second part overviews the present knowledge of spindle activity during development and the ability of NSBs to organize immature circuits. Studies linking abnormal maturation of brain wiring with neurological and neuropsychiatric disorders highlight the importance to better elucidate neonatal plasticity rules in future research. |
| format | Article |
| id | doaj-art-2f3a3b22e75b4e9e87b5c71a5759720f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2f3a3b22e75b4e9e87b5c71a5759720f2025-02-03T07:25:29ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/57874235787423Spindle Activity Orchestrates Plasticity during Development and SleepChristoph Lindemann0Joachim Ahlbeck1Sebastian H. Bitzenhofer2Ileana L. Hanganu-Opatz3Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, GermanyDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, GermanySpindle oscillations have been described during early brain development and in the adult brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle bursts (NSBs) and adult sleep spindles (ASSs) show differences in their occurrence, spatial distribution, and underlying mechanisms. While NSBs have been proposed to coordinate the refinement of the maturating neuronal network, ASSs are associated with the implementation of acquired information within existing networks. Along with these functional differences, separate synaptic plasticity mechanisms seem to be recruited. Here, we review the generation of spindle oscillations in the developing and adult brain and discuss possible implications of their differences for synaptic plasticity. The first part of the review is dedicated to the generation and function of ASSs with a particular focus on their role in healthy and impaired neuronal networks. The second part overviews the present knowledge of spindle activity during development and the ability of NSBs to organize immature circuits. Studies linking abnormal maturation of brain wiring with neurological and neuropsychiatric disorders highlight the importance to better elucidate neonatal plasticity rules in future research.http://dx.doi.org/10.1155/2016/5787423 |
| spellingShingle | Christoph Lindemann Joachim Ahlbeck Sebastian H. Bitzenhofer Ileana L. Hanganu-Opatz Spindle Activity Orchestrates Plasticity during Development and Sleep Neural Plasticity |
| title | Spindle Activity Orchestrates Plasticity during Development and Sleep |
| title_full | Spindle Activity Orchestrates Plasticity during Development and Sleep |
| title_fullStr | Spindle Activity Orchestrates Plasticity during Development and Sleep |
| title_full_unstemmed | Spindle Activity Orchestrates Plasticity during Development and Sleep |
| title_short | Spindle Activity Orchestrates Plasticity during Development and Sleep |
| title_sort | spindle activity orchestrates plasticity during development and sleep |
| url | http://dx.doi.org/10.1155/2016/5787423 |
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