Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia
The placenta plays a central role in governing local circulatory system that mediates maternal condition and fetal growth. In early gestational phases, the placenta exerts properties of invasion and neovascularization for successful placentation. Extravillous invasive trophoblasts replace uterine en...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/123717 |
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| author | Mitsuko Furuya Kentaro Kurasawa Kiyotaka Nagahama Kae Kawachi Akinori Nozawa Tsuneo Takahashi Ichiro Aoki |
| author_facet | Mitsuko Furuya Kentaro Kurasawa Kiyotaka Nagahama Kae Kawachi Akinori Nozawa Tsuneo Takahashi Ichiro Aoki |
| author_sort | Mitsuko Furuya |
| collection | DOAJ |
| description | The placenta plays a central role in governing local circulatory system that mediates maternal condition and fetal growth. In early gestational phases, the placenta exerts properties of invasion and neovascularization for successful placentation. Extravillous invasive trophoblasts replace uterine endometrial vasculature and establish local blood pathway to obtain oxygen and nutrients from the mother. In later phases, the placenta promotes villous angiogenesis and vascular maturation that are finely controlled by angiogenic and antiangiogenic molecules. Among various molecules involved in placental neovascularization, vascular endothelial growth factor receptors (VEGFRs) and angiotensin II receptor type 1 (AT1) mediate important signaling pathways for maternal circulatory system and fetal growth. VEGFR1 and VEGFR2 are functional receptors for placental growth factor (PlGF) and VEGF, respectively, and PlGF-VEGFR1 and VEGF-VEGFR2 interactions are disturbed in many preeclamptic patients by excess amount of soluble form of VEGFR1 (also named sFlt1), a natural PlGF/VEGF antagonist. Recent studies have disclosed that excessive sFlt1 production in the placenta and aberrant AT1 signaling in the mother are closely associated with the pathology of preeclampsia and intrauterine growth restriction (IUGR). In this paper, neovascularization of the placenta and pathological events associated with disrupted balance between angiogenic and antiangiogenic signaling in preeclampsia are discussed. |
| format | Article |
| id | doaj-art-2f2f4f4d6d164bb69b5cb164a44a3a56 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-2f2f4f4d6d164bb69b5cb164a44a3a562025-02-03T06:12:37ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/123717123717Disrupted Balance of Angiogenic and Antiangiogenic Signalings in PreeclampsiaMitsuko Furuya0Kentaro Kurasawa1Kiyotaka Nagahama2Kae Kawachi3Akinori Nozawa4Tsuneo Takahashi5Ichiro Aoki6Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, JapanDepartment of Obstetrics, Yokohama City University Medical Center, Yokohama 232-0024, JapanDepartment of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, JapanDepartment of Pathology, Yokohama City University Medical Center, Yokohama 232-0024, JapanDepartment of Pathology, Yokohama City University Medical Center, Yokohama 232-0024, JapanDepartment of Obstetrics, Yokohama City University Medical Center, Yokohama 232-0024, JapanDepartment of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, JapanThe placenta plays a central role in governing local circulatory system that mediates maternal condition and fetal growth. In early gestational phases, the placenta exerts properties of invasion and neovascularization for successful placentation. Extravillous invasive trophoblasts replace uterine endometrial vasculature and establish local blood pathway to obtain oxygen and nutrients from the mother. In later phases, the placenta promotes villous angiogenesis and vascular maturation that are finely controlled by angiogenic and antiangiogenic molecules. Among various molecules involved in placental neovascularization, vascular endothelial growth factor receptors (VEGFRs) and angiotensin II receptor type 1 (AT1) mediate important signaling pathways for maternal circulatory system and fetal growth. VEGFR1 and VEGFR2 are functional receptors for placental growth factor (PlGF) and VEGF, respectively, and PlGF-VEGFR1 and VEGF-VEGFR2 interactions are disturbed in many preeclamptic patients by excess amount of soluble form of VEGFR1 (also named sFlt1), a natural PlGF/VEGF antagonist. Recent studies have disclosed that excessive sFlt1 production in the placenta and aberrant AT1 signaling in the mother are closely associated with the pathology of preeclampsia and intrauterine growth restriction (IUGR). In this paper, neovascularization of the placenta and pathological events associated with disrupted balance between angiogenic and antiangiogenic signaling in preeclampsia are discussed.http://dx.doi.org/10.1155/2011/123717 |
| spellingShingle | Mitsuko Furuya Kentaro Kurasawa Kiyotaka Nagahama Kae Kawachi Akinori Nozawa Tsuneo Takahashi Ichiro Aoki Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia Journal of Pregnancy |
| title | Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia |
| title_full | Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia |
| title_fullStr | Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia |
| title_full_unstemmed | Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia |
| title_short | Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia |
| title_sort | disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia |
| url | http://dx.doi.org/10.1155/2011/123717 |
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