Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico.
<h4>Background</h4>Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO).<h4>Methods/ principal findings<...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-02-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009133&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469118603853824 |
|---|---|
| author | Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) |
| author_facet | Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) |
| author_sort | Pablo F Belaunzarán-Zamudio |
| collection | DOAJ |
| description | <h4>Background</h4>Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO).<h4>Methods/ principal findings</h4>This was a two-year, multicenter, observational, prospective, cohort study. We collected data from patients meeting the Pan American Health Organization's modified case-definition criteria for probable Zika infection. We identified Zika, dengue chikungunya by RT-PCR in serum and urine. We compared characteristics between patients with confirmed Zika and dengue infections, Zika and AIUO, and Dengue and AIUO at baseline, Days 3,7,28 and 180 of follow-up. Most episodes (67%) consistent with the PAHO definition of probable Zika could not be confirmed as due to any flavivirus and classified as Acute Illnesses of Unidentified Origin (AIUO). Infections by Zika and dengue accounted for 8.4% and 16% of episodes. Dengue patients presented with fever, generalized non-macular rash, arthralgia, and petechiae more frequently than patients with Zika during the first 10 days of symptoms. Dengue patients presented with more laboratory abnormalities (lower neutrophils, lymphocytosis, thrombocytopenia and abnormal liver function tests), with thrombocytopenia lasting for 28 days. Zika patients had conjunctivitis, photophobia and localized macular rash more frequently than others. Few differences persisted longer than 10 days after symptoms initiation: conjunctivitis in Zika infections, and self-reported rash and petechia in dengue infections.<h4>Conclusions</h4>Our study helps characterize the variety and duration of clinical features in patients with Zika, dengue and AIUO. The lack of diagnosis in most patients points to need for better diagnostics to assist clinicians in making specific etiologic diagnoses. |
| format | Article |
| id | doaj-art-2f15c9dcd5fb4ecc968b38fea6b1ced9 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-2f15c9dcd5fb4ecc968b38fea6b1ced92025-08-20T03:25:38ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-02-01152e000913310.1371/journal.pntd.0009133Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico.Pablo F Belaunzarán-ZamudioAllyson MatejaPaola Del Carmen Guerra-de-BlasHéctor A Rincón-LeónKarla Navarro-FuentesEmilia Ruiz-HernándezSandra Caballero-SosaFrancisco Camas-DuránZoila Priego-SmithJosé G Nájera-CancinoAlexander López-RobleroKarina Del Carmen Trujillo-MurilloJohn H PowersSally HunsbergerSophia SiddiquiJohn H BeigelRaydel Valdés-SalgadoGuillermo Ruiz-PalaciosMexican Emerging Infectious Diseases Clinical Research Network (LaRed)<h4>Background</h4>Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO).<h4>Methods/ principal findings</h4>This was a two-year, multicenter, observational, prospective, cohort study. We collected data from patients meeting the Pan American Health Organization's modified case-definition criteria for probable Zika infection. We identified Zika, dengue chikungunya by RT-PCR in serum and urine. We compared characteristics between patients with confirmed Zika and dengue infections, Zika and AIUO, and Dengue and AIUO at baseline, Days 3,7,28 and 180 of follow-up. Most episodes (67%) consistent with the PAHO definition of probable Zika could not be confirmed as due to any flavivirus and classified as Acute Illnesses of Unidentified Origin (AIUO). Infections by Zika and dengue accounted for 8.4% and 16% of episodes. Dengue patients presented with fever, generalized non-macular rash, arthralgia, and petechiae more frequently than patients with Zika during the first 10 days of symptoms. Dengue patients presented with more laboratory abnormalities (lower neutrophils, lymphocytosis, thrombocytopenia and abnormal liver function tests), with thrombocytopenia lasting for 28 days. Zika patients had conjunctivitis, photophobia and localized macular rash more frequently than others. Few differences persisted longer than 10 days after symptoms initiation: conjunctivitis in Zika infections, and self-reported rash and petechia in dengue infections.<h4>Conclusions</h4>Our study helps characterize the variety and duration of clinical features in patients with Zika, dengue and AIUO. The lack of diagnosis in most patients points to need for better diagnostics to assist clinicians in making specific etiologic diagnoses.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009133&type=printable |
| spellingShingle | Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. PLoS Neglected Tropical Diseases |
| title | Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
| title_full | Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
| title_fullStr | Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
| title_full_unstemmed | Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
| title_short | Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
| title_sort | comparison of clinical characteristics of zika and dengue symptomatic infections and other acute illnesses of unidentified origin in mexico |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009133&type=printable |
| work_keys_str_mv | AT pablofbelaunzaranzamudio comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT allysonmateja comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT paoladelcarmenguerradeblas comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT hectorarinconleon comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT karlanavarrofuentes comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT emiliaruizhernandez comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT sandracaballerososa comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT franciscocamasduran comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT zoilapriegosmith comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT josegnajeracancino comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT alexanderlopezroblero comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT karinadelcarmentrujillomurillo comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT johnhpowers comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT sallyhunsberger comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT sophiasiddiqui comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT johnhbeigel comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT raydelvaldessalgado comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT guillermoruizpalacios comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico AT mexicanemerginginfectiousdiseasesclinicalresearchnetworklared comparisonofclinicalcharacteristicsofzikaanddenguesymptomaticinfectionsandotheracuteillnessesofunidentifiedorigininmexico |