Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet
Moringa oleifera (MO) is a native tree of Asia and is cultivated in some areas of Mexico as part of traditional horticulture. The aim of the present study was to compare the efficacy of MO infusion vs. MO ethanolic extract for the simultaneous treatment of nonalcoholic fatty liver (NAFLD), hyperlipi...
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2024-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2024/2209581 |
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| author | Salma I. Cortes-Alvarez Ivan Delgado-Enciso Alejandrina Rodriguez-Hernandez Gustavo A. Hernandez-Fuentes Nomely S. Aurelien-Cabezas Norma A. Moy-Lopez Nadia Y. Cortes-Alvarez Jorge Guzman-Muñiz Jose Guzman-Esquivel Iram P. Rodriguez-Sanchez Margarita L. Martinez-Fierro Karen A. Mokay-Ramirez Carlos E. Barajas-Saucedo Carmen A. Sanchez-Ramirez |
| author_facet | Salma I. Cortes-Alvarez Ivan Delgado-Enciso Alejandrina Rodriguez-Hernandez Gustavo A. Hernandez-Fuentes Nomely S. Aurelien-Cabezas Norma A. Moy-Lopez Nadia Y. Cortes-Alvarez Jorge Guzman-Muñiz Jose Guzman-Esquivel Iram P. Rodriguez-Sanchez Margarita L. Martinez-Fierro Karen A. Mokay-Ramirez Carlos E. Barajas-Saucedo Carmen A. Sanchez-Ramirez |
| author_sort | Salma I. Cortes-Alvarez |
| collection | DOAJ |
| description | Moringa oleifera (MO) is a native tree of Asia and is cultivated in some areas of Mexico as part of traditional horticulture. The aim of the present study was to compare the efficacy of MO infusion vs. MO ethanolic extract for the simultaneous treatment of nonalcoholic fatty liver (NAFLD), hyperlipidemia, and hyperglycemia in a murine model fed with a high-fat diet (HFD). BALB/c mice were fed a balanced diet (healthy control) or an HFD for 6 months. With this, the NAFLD model was established before starting a therapeutic intervention with MO for two months. The phytochemical analysis by nuclear magnetic resonance in 1H and 13C experiments showed signals for pyrrole alkaloids and triterpenes as the main constituents of the extract and infusion preparation. A significant reduction of SGPT, SGOT, lipids, urea, and glucose in blood among NAFLD groups treated with MO (infusion or extract) was found, when compared to the NAFLD-placebo group. Steatosis and liver inflammation were found to be decreased in the MO groups, as infusion or ethanolic extract. Infusion produced a better therapeutic effect than the extract in all parameters, except glycemic control, where the extract was better. As an additional finding, it is noteworthy that treatment with MO, particularly through infusion, resulted in improved motor activity. Moreover, a reduction in anxiety-like behavior was observed exclusively with the administration of infusion. These observations provide valuable insights into the potential broader effects of Moringa oleifera beyond the primary aim of the study. |
| format | Article |
| id | doaj-art-2f12427cfcd94847814ed1defa8b45bc |
| institution | Kabale University |
| issn | 2090-0732 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
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| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-2f12427cfcd94847814ed1defa8b45bc2025-02-03T01:31:59ZengWileyJournal of Nutrition and Metabolism2090-07322024-01-01202410.1155/2024/2209581Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat DietSalma I. Cortes-Alvarez0Ivan Delgado-Enciso1Alejandrina Rodriguez-Hernandez2Gustavo A. Hernandez-Fuentes3Nomely S. Aurelien-Cabezas4Norma A. Moy-Lopez5Nadia Y. Cortes-Alvarez6Jorge Guzman-Muñiz7Jose Guzman-Esquivel8Iram P. Rodriguez-Sanchez9Margarita L. Martinez-Fierro10Karen A. Mokay-Ramirez11Carlos E. Barajas-Saucedo12Carmen A. Sanchez-Ramirez13Department of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineLaboratory of NeuroscienceLaboratory of NeuroscienceLaboratory of NeuroscienceDepartment of ResearchMolecular and Structural Physiology LaboratoryMolecular Medicine LaboratoryDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineDepartment of Molecular Medicine and Nutrition Laboratory at School of MedicineMoringa oleifera (MO) is a native tree of Asia and is cultivated in some areas of Mexico as part of traditional horticulture. The aim of the present study was to compare the efficacy of MO infusion vs. MO ethanolic extract for the simultaneous treatment of nonalcoholic fatty liver (NAFLD), hyperlipidemia, and hyperglycemia in a murine model fed with a high-fat diet (HFD). BALB/c mice were fed a balanced diet (healthy control) or an HFD for 6 months. With this, the NAFLD model was established before starting a therapeutic intervention with MO for two months. The phytochemical analysis by nuclear magnetic resonance in 1H and 13C experiments showed signals for pyrrole alkaloids and triterpenes as the main constituents of the extract and infusion preparation. A significant reduction of SGPT, SGOT, lipids, urea, and glucose in blood among NAFLD groups treated with MO (infusion or extract) was found, when compared to the NAFLD-placebo group. Steatosis and liver inflammation were found to be decreased in the MO groups, as infusion or ethanolic extract. Infusion produced a better therapeutic effect than the extract in all parameters, except glycemic control, where the extract was better. As an additional finding, it is noteworthy that treatment with MO, particularly through infusion, resulted in improved motor activity. Moreover, a reduction in anxiety-like behavior was observed exclusively with the administration of infusion. These observations provide valuable insights into the potential broader effects of Moringa oleifera beyond the primary aim of the study.http://dx.doi.org/10.1155/2024/2209581 |
| spellingShingle | Salma I. Cortes-Alvarez Ivan Delgado-Enciso Alejandrina Rodriguez-Hernandez Gustavo A. Hernandez-Fuentes Nomely S. Aurelien-Cabezas Norma A. Moy-Lopez Nadia Y. Cortes-Alvarez Jorge Guzman-Muñiz Jose Guzman-Esquivel Iram P. Rodriguez-Sanchez Margarita L. Martinez-Fierro Karen A. Mokay-Ramirez Carlos E. Barajas-Saucedo Carmen A. Sanchez-Ramirez Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet Journal of Nutrition and Metabolism |
| title | Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet |
| title_full | Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet |
| title_fullStr | Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet |
| title_full_unstemmed | Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet |
| title_short | Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet |
| title_sort | efficacy of hot tea infusion vs ethanolic extract of moringa oleifera for the simultaneous treatment of nonalcoholic fatty liver hyperlipidemia and hyperglycemia in a murine model fed with a high fat diet |
| url | http://dx.doi.org/10.1155/2024/2209581 |
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