Most relevant genetic factors in ovarian cancer development
Ovarian cancer (OC) represents a significant challenge in the realm of gynecological cancers, characterized by poor survival rates and complex etiology. This review delves into the genetic, environmental, and hormonal factors underpinning OC development, shedding light on both well-established contr...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2025-01-01
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| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2025001 |
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| Summary: | Ovarian cancer (OC) represents a significant challenge in the realm of gynecological cancers, characterized by poor survival rates and complex etiology. This review delves into the genetic, environmental, and hormonal factors underpinning OC development, shedding light on both well-established contributors and emerging influences. We reviewed scientific databases searching for OC genetic and epigenetic factors and included studies based on their relevancy. As a result of exploring ovarian carcinogenesis, this systematic review contains data collected from 102 works. The role of prominent genetic players, such as BRCA mutations and DNA repair mechanisms, underscores the intricate landscape of OC susceptibility. Furthermore, we explore Li-Fraumeni and Lynch syndrome, which result in a heightened predisposition to OC development. Hormonal factors such as estrogen, progesterone, and androgens are also discussed in detail. Environmental alterations, ranging from lifestyle influences to microbiome dysbiosis add layers of complexity to OC pathogenesis. Lifestyle factors such as obesity, alcohol consumption, and physical activity intersect with genetic and epigenetic pathways, shaping the risk landscape for OC. This review provides a nuanced understanding of the multifactorial nature of OC through a meticulous examination of current literature, emphasizing the need for holistic approaches to prevention, diagnosis, and treatment. |
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| ISSN: | 2372-0301 |