Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH

Aims: Reactive oxygen species (ROS) play an important role in the pathogenesis of pulmonary arterial hypertension (PAH) and NADPH oxidases (NOXs) as sources of ROS are implicated in the development of the disease. We previously showed that NOX isozyme 1 (NOX1)-derived ROS contributes to pulmonary va...

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Bibliographic Details
Main Authors: Christian J. Goossen, Alex Kufner, Christopher M. Dustin, Imad Al Ghouleh, Shuai Yuan, Adam C. Straub, John Sembrat, Jeffrey J. Baust, Delphine Gomez, Damir Kračun, Patrick J. Pagano
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
NADPH oxidases
NOXA1ds
NOX inhibitors
Hypoxia
Unfolded protein response
Pulmonary arterial hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000679
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