Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue
It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obes...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/823486 |
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| author | Odile Poulain-Godefroy Olivier Le Bacquer Pauline Plancq Cécile Lecœur François Pattou Gema Frühbeck Philippe Froguel |
| author_facet | Odile Poulain-Godefroy Olivier Le Bacquer Pauline Plancq Cécile Lecœur François Pattou Gema Frühbeck Philippe Froguel |
| author_sort | Odile Poulain-Godefroy |
| collection | DOAJ |
| description | It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject. We demonstrated a correlation of TLRs expression within and between each depot suggesting a coregulation. Murine 3T3-L1 preadipocyte cells stimulated with Pam3CSK4 induced the expression of some proinflammatory markers. Therefore, beside TLR4, other toll-like receptors are differentially expressed in human fat tissue, and functional in an adipocyte cell line, suggesting that they might participate omental adipose tissue-related inflammation that occurs in obesity. |
| format | Article |
| id | doaj-art-2eeaa9dd7005429687a7ea4c914a683e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2eeaa9dd7005429687a7ea4c914a683e2025-02-03T01:22:23ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/823486823486Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose TissueOdile Poulain-Godefroy0Olivier Le Bacquer1Pauline Plancq2Cécile Lecœur3François Pattou4Gema Frühbeck5Philippe Froguel6CNRS 8199-Institute of Biology, Pasteur Institute, 59019 Lille, FranceCNRS 8199-Institute of Biology, Pasteur Institute, 59019 Lille, FranceCNRS 8199-Institute of Biology, Pasteur Institute, 59019 Lille, FranceCNRS 8199-Institute of Biology, Pasteur Institute, 59019 Lille, FranceINSERM U859, IFR114 IMPRT, Faculté de Médecine, Pôle Recherche, 59045 Lille, FranceDepartment of Endocrinology, Clínica Universitaria de Navarra, Universitaria de Navarra, Univ. Navarra, and CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 31008 Pamplona, SpainCNRS 8199-Institute of Biology, Pasteur Institute, 59019 Lille, FranceIt was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject. We demonstrated a correlation of TLRs expression within and between each depot suggesting a coregulation. Murine 3T3-L1 preadipocyte cells stimulated with Pam3CSK4 induced the expression of some proinflammatory markers. Therefore, beside TLR4, other toll-like receptors are differentially expressed in human fat tissue, and functional in an adipocyte cell line, suggesting that they might participate omental adipose tissue-related inflammation that occurs in obesity.http://dx.doi.org/10.1155/2010/823486 |
| spellingShingle | Odile Poulain-Godefroy Olivier Le Bacquer Pauline Plancq Cécile Lecœur François Pattou Gema Frühbeck Philippe Froguel Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue Mediators of Inflammation |
| title | Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue |
| title_full | Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue |
| title_fullStr | Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue |
| title_full_unstemmed | Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue |
| title_short | Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue |
| title_sort | inflammatory role of toll like receptors in human and murine adipose tissue |
| url | http://dx.doi.org/10.1155/2010/823486 |
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