Resveratrol—A Promising Therapeutic Agent with Problematic Properties
Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, in particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant and cardioprotective activity, are the main reas...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587699467321344 |
|---|---|
| author | Lyubomira Radeva Krassimira Yoncheva |
| author_facet | Lyubomira Radeva Krassimira Yoncheva |
| author_sort | Lyubomira Radeva |
| collection | DOAJ |
| description | Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, in particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant and cardioprotective activity, are the main reason for its importance in medicine and pharmacy. Despite all of its advantages, however, there are many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability and fast metabolism. For this reason, scientists are currently searching for different approaches to dealing with these problematic properties and improving the therapeutic usage of resveratrol. This review summarizes the mechanisms of the biological effects of resveratrol, determined in vitro and in vivo, and the main limitations of the drug. The article emphasizes new approaches for the improvement of resveratrol delivery, in particular nanoencapsulation, formation of nanocrystals, prodrugs and structure analogues. |
| format | Article |
| id | doaj-art-2ee6747b64f941498ce5f4581d307d50 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-2ee6747b64f941498ce5f4581d307d502025-01-24T13:46:06ZengMDPI AGPharmaceutics1999-49232025-01-0117113410.3390/pharmaceutics17010134Resveratrol—A Promising Therapeutic Agent with Problematic PropertiesLyubomira Radeva0Krassimira Yoncheva1Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaResveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, in particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant and cardioprotective activity, are the main reason for its importance in medicine and pharmacy. Despite all of its advantages, however, there are many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability and fast metabolism. For this reason, scientists are currently searching for different approaches to dealing with these problematic properties and improving the therapeutic usage of resveratrol. This review summarizes the mechanisms of the biological effects of resveratrol, determined in vitro and in vivo, and the main limitations of the drug. The article emphasizes new approaches for the improvement of resveratrol delivery, in particular nanoencapsulation, formation of nanocrystals, prodrugs and structure analogues.https://www.mdpi.com/1999-4923/17/1/134resveratrolbiological activitiesnanoencapsulationnanocrystalsprodrugsstructure analogues |
| spellingShingle | Lyubomira Radeva Krassimira Yoncheva Resveratrol—A Promising Therapeutic Agent with Problematic Properties Pharmaceutics resveratrol biological activities nanoencapsulation nanocrystals prodrugs structure analogues |
| title | Resveratrol—A Promising Therapeutic Agent with Problematic Properties |
| title_full | Resveratrol—A Promising Therapeutic Agent with Problematic Properties |
| title_fullStr | Resveratrol—A Promising Therapeutic Agent with Problematic Properties |
| title_full_unstemmed | Resveratrol—A Promising Therapeutic Agent with Problematic Properties |
| title_short | Resveratrol—A Promising Therapeutic Agent with Problematic Properties |
| title_sort | resveratrol a promising therapeutic agent with problematic properties |
| topic | resveratrol biological activities nanoencapsulation nanocrystals prodrugs structure analogues |
| url | https://www.mdpi.com/1999-4923/17/1/134 |
| work_keys_str_mv | AT lyubomiraradeva resveratrolapromisingtherapeuticagentwithproblematicproperties AT krassimirayoncheva resveratrolapromisingtherapeuticagentwithproblematicproperties |