Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes
Background: Narcolepsy, obesity, and attention deficit hyperactivity disorder are all treated with amphetamine (a central nervous system stimulant) while valerenic acid (VA) has a pharmacological effect in the central nervous system. Objectives: The purpose of this study was to ascertain whether VA...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475002500054X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573133442252800 |
|---|---|
| author | Khaled M.M. Koriem Ammar H.A. Naiem |
| author_facet | Khaled M.M. Koriem Ammar H.A. Naiem |
| author_sort | Khaled M.M. Koriem |
| collection | DOAJ |
| description | Background: Narcolepsy, obesity, and attention deficit hyperactivity disorder are all treated with amphetamine (a central nervous system stimulant) while valerenic acid (VA) has a pharmacological effect in the central nervous system. Objectives: The purpose of this study was to ascertain whether VA is able to make amends for neurotoxicity by modifying hypothalamus expressions of the enzymes tyrosine hydroxylase and histamine-N-methyl transferase in rats orally administered with methamphetamine (METH). Methods: There were thirty-six male albino rats split up into six equal groups, Control, VA (5 mg/kg)-treated, and VA (10 mg/kg)-treated groups: For four weeks, normal rats received oral administration of 1 ml of distilled water, 5 mg/kg of VA, and 10 ml/kg of VA once daily. METH-treated, VA (5 mg/kg) prior to METH-treated, and VA (10 mg/kg) before METH-treated groups: normal rats were oral administrated with METH (2.5 mg/kg), 3 days/week for 3 weeks, where the last two groups were oral administrated daily during four weeks at 5 mg/kg and 10 mg/kg VA, starting one week prior to METH administration. Results: METH decreased superoxide dismutase, glutathione peroxidase, catalase, NADPH oxidase, interleukin-10, sucrose preference test, distance traveled test, and center square entries test, ATPase activity and the enzymes tyrosine hydroxylase and histamine-N-methyl transferase but increased malondialdehyde, conjugated dienes, oxidative index, serotonin, dopamine, norepinephrine, γ-aminobutyric acid, tumor necrosis factor-α, interleukin-1β, interleukin-6, nuclear factor kappa B levels, the center square duration test, tail suspension test, and forced swimming test. in the METH-treated animals' brain in contrast to the control group. After four weeks of oral administration of VA to METH-treated rats, all of these parameters returned to levels that were nearly control, indicating that a higher dose was more effective than a lower one. Conclusion: VA ameliorated METH-related neurotoxicity by improving hypothamalus expressions of the enzymes tyrosine hydroxylase and histamine-N-methyl transferase. |
| format | Article |
| id | doaj-art-2ee05876e6ae4d06b6c0c60c011b2ed9 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-2ee05876e6ae4d06b6c0c60c011b2ed92025-02-02T05:27:36ZengElsevierToxicology Reports2214-75002025-06-0114101936Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymesKhaled M.M. Koriem0Ammar H.A. Naiem1Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt; Correspondence to: Medical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, P.O. Box. 12622, 33 El-Buhouth Street, Dokki, Giza, Egypt.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, EgyptBackground: Narcolepsy, obesity, and attention deficit hyperactivity disorder are all treated with amphetamine (a central nervous system stimulant) while valerenic acid (VA) has a pharmacological effect in the central nervous system. Objectives: The purpose of this study was to ascertain whether VA is able to make amends for neurotoxicity by modifying hypothalamus expressions of the enzymes tyrosine hydroxylase and histamine-N-methyl transferase in rats orally administered with methamphetamine (METH). Methods: There were thirty-six male albino rats split up into six equal groups, Control, VA (5 mg/kg)-treated, and VA (10 mg/kg)-treated groups: For four weeks, normal rats received oral administration of 1 ml of distilled water, 5 mg/kg of VA, and 10 ml/kg of VA once daily. METH-treated, VA (5 mg/kg) prior to METH-treated, and VA (10 mg/kg) before METH-treated groups: normal rats were oral administrated with METH (2.5 mg/kg), 3 days/week for 3 weeks, where the last two groups were oral administrated daily during four weeks at 5 mg/kg and 10 mg/kg VA, starting one week prior to METH administration. Results: METH decreased superoxide dismutase, glutathione peroxidase, catalase, NADPH oxidase, interleukin-10, sucrose preference test, distance traveled test, and center square entries test, ATPase activity and the enzymes tyrosine hydroxylase and histamine-N-methyl transferase but increased malondialdehyde, conjugated dienes, oxidative index, serotonin, dopamine, norepinephrine, γ-aminobutyric acid, tumor necrosis factor-α, interleukin-1β, interleukin-6, nuclear factor kappa B levels, the center square duration test, tail suspension test, and forced swimming test. in the METH-treated animals' brain in contrast to the control group. After four weeks of oral administration of VA to METH-treated rats, all of these parameters returned to levels that were nearly control, indicating that a higher dose was more effective than a lower one. Conclusion: VA ameliorated METH-related neurotoxicity by improving hypothamalus expressions of the enzymes tyrosine hydroxylase and histamine-N-methyl transferase.http://www.sciencedirect.com/science/article/pii/S221475002500054XValerenic acidMethamphetamineSerotoninTyrosine hydroxylaseInterleukin-1β |
| spellingShingle | Khaled M.M. Koriem Ammar H.A. Naiem Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes Toxicology Reports Valerenic acid Methamphetamine Serotonin Tyrosine hydroxylase Interleukin-1β |
| title | Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes |
| title_full | Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes |
| title_fullStr | Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes |
| title_full_unstemmed | Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes |
| title_short | Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes |
| title_sort | valerenic acid ameliorates amphetamine related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine n methyl transferase enzymes |
| topic | Valerenic acid Methamphetamine Serotonin Tyrosine hydroxylase Interleukin-1β |
| url | http://www.sciencedirect.com/science/article/pii/S221475002500054X |
| work_keys_str_mv | AT khaledmmkoriem valerenicacidamelioratesamphetaminerelatedneurotoxicitybyimprovinghypothalamustyrosinehydroxylaseandhistaminenmethyltransferaseenzymes AT ammarhanaiem valerenicacidamelioratesamphetaminerelatedneurotoxicitybyimprovinghypothalamustyrosinehydroxylaseandhistaminenmethyltransferaseenzymes |