Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study
Background. There is still considerable uncertainty in handling vitamin D deficiency in people living with HIV (PLWH), due to a lack of comparative data and the wide range of recommended daily intake. Nondaily supplementation might be preferred in many PLWH, but recommendation on dosing has not been...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/7502127 |
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| author | Sebastian Noe Christine I. Moeckel Christiane Schwerdtfeger Celia Oldenbuettel Hans Jaeger Eva Wolf Christoph D. Spinner |
| author_facet | Sebastian Noe Christine I. Moeckel Christiane Schwerdtfeger Celia Oldenbuettel Hans Jaeger Eva Wolf Christoph D. Spinner |
| author_sort | Sebastian Noe |
| collection | DOAJ |
| description | Background. There is still considerable uncertainty in handling vitamin D deficiency in people living with HIV (PLWH), due to a lack of comparative data and the wide range of recommended daily intake. Nondaily supplementation might be preferred in many PLWH, but recommendation on dosing has not been established. We aimed to compare the efficacy of weekly versus monthly supplementation with cholecalciferol 20,000 IU in a group of PLWH with vitamin D deficiency in Western Europe. Study Design. Longitudinal, retrospective nested cohort study of PLWH from two large clinical care centers in Munich, Germany. Results. Of 307 patients with vitamin D deficiency, 124 patients received vitamin D supplementation (weekly supplementation in 84 (67.7%)). 46.4% and 22.5% of patients achieved 25(OH)D levels ≥30 ng/mL after 12 months of weekly and monthly supplementation with cholecalciferol 20,000 IU, respectively (p=0.011). Dosing interval as well as 25(OH)D baseline levels >15 ng/mL were associated with the normalization of 25(OH)D. Conclusion. A higher rate of 25(OH)D level normalization can be achieved via weekly supplementation. For several PLWH, even a weekly dose of cholecalciferol 20,000 IU might not be adequate to maintain 25(OH)D levels >30 ng/mL without an initial “loading” dose. The response to supplementation is poorly predictable at an individual level. |
| format | Article |
| id | doaj-art-2edcf55490e34c45858d6bc3cac5f083 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-2edcf55490e34c45858d6bc3cac5f0832025-02-03T01:30:55ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982018-01-01201810.1155/2018/75021277502127Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort StudySebastian Noe0Christine I. Moeckel1Christiane Schwerdtfeger2Celia Oldenbuettel3Hans Jaeger4Eva Wolf5Christoph D. Spinner6MVZ Karlsplatz, Research and Clinical Care Center, 80335 Munich, GermanyUniversity Hospital Klinikum rechts der Isar, Department of Medicine II, Technische Universität München, 80675 Munich, GermanyUniversity Hospital Klinikum rechts der Isar, Department of Medicine II, Technische Universität München, 80675 Munich, GermanyMVZ Karlsplatz, Research and Clinical Care Center, 80335 Munich, GermanyMVZ Karlsplatz, Research and Clinical Care Center, 80335 Munich, GermanyMUC Research, Private Research Organization, 80335 Munich, GermanyUniversity Hospital Klinikum rechts der Isar, Department of Medicine II, Technische Universität München, 80675 Munich, GermanyBackground. There is still considerable uncertainty in handling vitamin D deficiency in people living with HIV (PLWH), due to a lack of comparative data and the wide range of recommended daily intake. Nondaily supplementation might be preferred in many PLWH, but recommendation on dosing has not been established. We aimed to compare the efficacy of weekly versus monthly supplementation with cholecalciferol 20,000 IU in a group of PLWH with vitamin D deficiency in Western Europe. Study Design. Longitudinal, retrospective nested cohort study of PLWH from two large clinical care centers in Munich, Germany. Results. Of 307 patients with vitamin D deficiency, 124 patients received vitamin D supplementation (weekly supplementation in 84 (67.7%)). 46.4% and 22.5% of patients achieved 25(OH)D levels ≥30 ng/mL after 12 months of weekly and monthly supplementation with cholecalciferol 20,000 IU, respectively (p=0.011). Dosing interval as well as 25(OH)D baseline levels >15 ng/mL were associated with the normalization of 25(OH)D. Conclusion. A higher rate of 25(OH)D level normalization can be achieved via weekly supplementation. For several PLWH, even a weekly dose of cholecalciferol 20,000 IU might not be adequate to maintain 25(OH)D levels >30 ng/mL without an initial “loading” dose. The response to supplementation is poorly predictable at an individual level.http://dx.doi.org/10.1155/2018/7502127 |
| spellingShingle | Sebastian Noe Christine I. Moeckel Christiane Schwerdtfeger Celia Oldenbuettel Hans Jaeger Eva Wolf Christoph D. Spinner Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study Interdisciplinary Perspectives on Infectious Diseases |
| title | Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study |
| title_full | Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study |
| title_fullStr | Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study |
| title_full_unstemmed | Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study |
| title_short | Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study |
| title_sort | monthly or weekly supplementation with cholecalciferol 20 000 iu in people living with hiv results from a nested cohort study |
| url | http://dx.doi.org/10.1155/2018/7502127 |
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