IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis

IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis

Abstract Background Interleukin-6 (IL-6) plays a central role in sepsis-induced cytokine storm involving immune hyperactivation and early neutrophil activation. Programmed death protein-1 (PD-1) is associated with sepsis-induced immunosuppression and lymphocyte apoptosis. However, the effects of sim...

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Bibliographic Details
Main Authors: Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Immunology
Subjects:
Activation, Lymphocyte
Activation, Neutrophil
Interleukin 6
Sepsis
Online Access:https://doi.org/10.1186/s12865-024-00679-z
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