Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection
Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological studies on the effect of treatment at this young age are scarce. In light of s...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/283619 |
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| author | Nadine Rujeni Norman Nausch Nicholas Midzi Graeme J. Cowan Richard Burchmore David R. Cavanagh David W. Taylor Takafira Mduluza Francisca Mutapi |
| author_facet | Nadine Rujeni Norman Nausch Nicholas Midzi Graeme J. Cowan Richard Burchmore David R. Cavanagh David W. Taylor Takafira Mduluza Francisca Mutapi |
| author_sort | Nadine Rujeni |
| collection | DOAJ |
| description | Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological studies on the effect of treatment at this young age are scarce. In light of studies in older individuals showing that praziquantel alters antischistosome immune responses and responses to bystander antigens, this study aims to investigate how these responses would be affected by treatment at this young age. Antibody responses directed against schistosome antigens, Plasmodium falciparum crude and recombinant antigens, and the allergen house dust mite were measured in children aged 3 to 5 years before and 6 weeks after treatment. The change in serological recognition of schistosome proteins was also investigated. Treatment augmented antischistosome IgM and IgE responses. The increase in IgE responses directed against adult worm antigens was accompanied by enhanced antigen recognition by sera from the children. Antibody responses directed against Plasmodium antigens were not significantly affected by praziquantel treatment nor were levels of allergen specific responses. Overall, praziquantel treatment enhanced, quantitatively and qualitatively, the antiworm responses associated with protective immunity but did not alter Plasmodium-specific responses or allergen-specific responses which mediate pathology in allergic disease. |
| format | Article |
| id | doaj-art-2ed00f24968547c592779fd1058d3706 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-2ed00f24968547c592779fd1058d37062025-02-03T06:42:28ZengWileyJournal of Tropical Medicine1687-96861687-96942013-01-01201310.1155/2013/283619283619Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome InfectionNadine Rujeni0Norman Nausch1Nicholas Midzi2Graeme J. Cowan3Richard Burchmore4David R. Cavanagh5David W. Taylor6Takafira Mduluza7Francisca Mutapi8 Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UKNational Institute of Health Research, Box CY 570, Causeway, Harare, Zimbabwe Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UKDivision of Pathway Medicine, School of Biomedical Sciences and Edinburgh Infectious Diseases, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UKDepartment of Biochemistry, University of Zimbabwe, P.O. Box 167, Mount Pleasant, Harare, Zimbabwe Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UKUrogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological studies on the effect of treatment at this young age are scarce. In light of studies in older individuals showing that praziquantel alters antischistosome immune responses and responses to bystander antigens, this study aims to investigate how these responses would be affected by treatment at this young age. Antibody responses directed against schistosome antigens, Plasmodium falciparum crude and recombinant antigens, and the allergen house dust mite were measured in children aged 3 to 5 years before and 6 weeks after treatment. The change in serological recognition of schistosome proteins was also investigated. Treatment augmented antischistosome IgM and IgE responses. The increase in IgE responses directed against adult worm antigens was accompanied by enhanced antigen recognition by sera from the children. Antibody responses directed against Plasmodium antigens were not significantly affected by praziquantel treatment nor were levels of allergen specific responses. Overall, praziquantel treatment enhanced, quantitatively and qualitatively, the antiworm responses associated with protective immunity but did not alter Plasmodium-specific responses or allergen-specific responses which mediate pathology in allergic disease.http://dx.doi.org/10.1155/2013/283619 |
| spellingShingle | Nadine Rujeni Norman Nausch Nicholas Midzi Graeme J. Cowan Richard Burchmore David R. Cavanagh David W. Taylor Takafira Mduluza Francisca Mutapi Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection Journal of Tropical Medicine |
| title | Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection |
| title_full | Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection |
| title_fullStr | Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection |
| title_full_unstemmed | Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection |
| title_short | Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection |
| title_sort | immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection |
| url | http://dx.doi.org/10.1155/2013/283619 |
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