Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China
We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/9620513 |
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| author | Xiao-Hong Pang Jue Han Wan-Lan Ye Xue Sun Yue Ding Wen-Juan Huang Yi-Ming Zhao Han-Yu Lou Li-Zhen Shan Ying-Xiu Kang Xiao-Xiao Song Song-Zhao Zhang Wei Gu Peng-Fei Shan |
| author_facet | Xiao-Hong Pang Jue Han Wan-Lan Ye Xue Sun Yue Ding Wen-Juan Huang Yi-Ming Zhao Han-Yu Lou Li-Zhen Shan Ying-Xiu Kang Xiao-Xiao Song Song-Zhao Zhang Wei Gu Peng-Fei Shan |
| author_sort | Xiao-Hong Pang |
| collection | DOAJ |
| description | We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index≤0.9 or >1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index>0.9 and ≤1.4; 1090 patients, 92.5%). Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, and statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P<0.05 for all). Logistic stepwise regression analysis indicated that ABI was an independent predictor of 10-year CHD and stroke risks in T2DM patients. Compared with those in the T2DM non-PAD group, the odds ratios (ORs) for CHD and stroke risk were 3.6 (95% confidence interval (CI), 2.2–6.0; P<0.001) and 6.9 (95% CI, 4.0–11.8; P<0.001) in those with lower extremity PAD, respectively. In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM. |
| format | Article |
| id | doaj-art-2ece218b5b614e418f63edfd1eaa21f3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2ece218b5b614e418f63edfd1eaa21f32025-02-03T05:57:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/96205139620513Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in ChinaXiao-Hong Pang0Jue Han1Wan-Lan Ye2Xue Sun3Yue Ding4Wen-Juan Huang5Yi-Ming Zhao6Han-Yu Lou7Li-Zhen Shan8Ying-Xiu Kang9Xiao-Xiao Song10Song-Zhao Zhang11Wei Gu12Peng-Fei Shan13Department of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, ChinaWe aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index≤0.9 or >1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index>0.9 and ≤1.4; 1090 patients, 92.5%). Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, and statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P<0.05 for all). Logistic stepwise regression analysis indicated that ABI was an independent predictor of 10-year CHD and stroke risks in T2DM patients. Compared with those in the T2DM non-PAD group, the odds ratios (ORs) for CHD and stroke risk were 3.6 (95% confidence interval (CI), 2.2–6.0; P<0.001) and 6.9 (95% CI, 4.0–11.8; P<0.001) in those with lower extremity PAD, respectively. In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM.http://dx.doi.org/10.1155/2017/9620513 |
| spellingShingle | Xiao-Hong Pang Jue Han Wan-Lan Ye Xue Sun Yue Ding Wen-Juan Huang Yi-Ming Zhao Han-Yu Lou Li-Zhen Shan Ying-Xiu Kang Xiao-Xiao Song Song-Zhao Zhang Wei Gu Peng-Fei Shan Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China International Journal of Endocrinology |
| title | Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China |
| title_full | Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China |
| title_fullStr | Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China |
| title_full_unstemmed | Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China |
| title_short | Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China |
| title_sort | lower extremity peripheral arterial disease is an independent predictor of coronary heart disease and stroke risks in patients with type 2 diabetes mellitus in china |
| url | http://dx.doi.org/10.1155/2017/9620513 |
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