n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes
Dietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations. The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2909210 |
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| author | André J. Tremblay Benoît Lamarche Jean-Charles Hogue Patrick Couture |
| author_facet | André J. Tremblay Benoît Lamarche Jean-Charles Hogue Patrick Couture |
| author_sort | André J. Tremblay |
| collection | DOAJ |
| description | Dietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations. The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA supplementation at 3 g/d for 8 weeks on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes. In vivo kinetics of the TG-rich lipoprotein (TRL) apoB-48 and VLDL apoB-100 were assessed using a primed-constant infusion of L-[5,5,5-D3] leucine for 12 hours in a fed state. Compared with the placebo, n-3 PUFA supplementation significantly reduced fasting TG concentrations by −9.7% (P=0.05) but also significantly increased plasma levels of cholesterol (C) (+6.0%, P=0.05), LDL-C (+12.2%, P=0.04), and HDL-C (+8.4, P=0.007). n-3 PUFA supplementation had no significant impact on postprandial TRL apoB-48 and VLDL apoB-100 levels or on the production or catabolic rates of these lipoproteins. These data indicate that 8-week supplementation with n-3 PUFAs in men with type 2 diabetes has no beneficial effect on TRL apoB-48 and VLDL apoB-100 levels or kinetics. |
| format | Article |
| id | doaj-art-2ecd7018668e4341a632ec6ea01140a6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2ecd7018668e4341a632ec6ea01140a62025-02-03T06:01:30ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/29092102909210n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 DiabetesAndré J. Tremblay0Benoît Lamarche1Jean-Charles Hogue2Patrick Couture3Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 0A6, CanadaInstitute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 0A6, CanadaInstitute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 0A6, CanadaInstitute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 0A6, CanadaDietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations. The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA supplementation at 3 g/d for 8 weeks on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes. In vivo kinetics of the TG-rich lipoprotein (TRL) apoB-48 and VLDL apoB-100 were assessed using a primed-constant infusion of L-[5,5,5-D3] leucine for 12 hours in a fed state. Compared with the placebo, n-3 PUFA supplementation significantly reduced fasting TG concentrations by −9.7% (P=0.05) but also significantly increased plasma levels of cholesterol (C) (+6.0%, P=0.05), LDL-C (+12.2%, P=0.04), and HDL-C (+8.4, P=0.007). n-3 PUFA supplementation had no significant impact on postprandial TRL apoB-48 and VLDL apoB-100 levels or on the production or catabolic rates of these lipoproteins. These data indicate that 8-week supplementation with n-3 PUFAs in men with type 2 diabetes has no beneficial effect on TRL apoB-48 and VLDL apoB-100 levels or kinetics.http://dx.doi.org/10.1155/2016/2909210 |
| spellingShingle | André J. Tremblay Benoît Lamarche Jean-Charles Hogue Patrick Couture n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes Journal of Diabetes Research |
| title | n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes |
| title_full | n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes |
| title_fullStr | n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes |
| title_full_unstemmed | n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes |
| title_short | n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes |
| title_sort | n 3 polyunsaturated fatty acid supplementation has no effect on postprandial triglyceride rich lipoprotein kinetics in men with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/2909210 |
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