SIRT3 mediates CPT2 delactylation to enhance mitochondrial function and proliferation in goat granulosa cells

SIRT3 mediates CPT2 delactylation to enhance mitochondrial function and proliferation in goat granulosa cells

Abstract Background Reproductive efficiency in goats is closely linked to the healthy development of follicles, with the proliferation of ovarian granulosa cells (GCs) playing a crucial role in this process. Sirtuin 3 (SIRT3), an enzyme that catalyzes post-translational modifications (PTMs) of prote...

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Bibliographic Details
Main Authors: Shuaifei Song, Mingzhi Yang, Jiayue Li, Yaru Li, Lei Wang, Shiyi Yao, Zihan Wang, Qiuyan Li, Yanguo Han, Dejun Xu, Zhongquan Zhao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Animal Science and Biotechnology
Subjects:
CPT2
Delactylation
Mitochondrial function
Ovarian granulosa cells
Proliferation
SIRT3
Online Access:https://doi.org/10.1186/s40104-025-01231-8
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