Development of the inner ear and regeneration of hair cells after hearing impairment
Hearing loss, as a sensory disorder, is the most common occurrence among humans, which has received increasing attention from society. It is mainly caused by the damage of inner ear hair cells (HCs) or the degeneration of spiral ganglion neurons. In mammals, cochlear HCs cannot regenerate naturally...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823002935 |
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| author | Xin Bing Chengcheng Liu Xue Cao Chengzhilin Li Xiaochen Gao Fangyuan Zhu Xinhao Wu Na Guo Houyang Hu Ming Xia Miaoqing Zhao |
| author_facet | Xin Bing Chengcheng Liu Xue Cao Chengzhilin Li Xiaochen Gao Fangyuan Zhu Xinhao Wu Na Guo Houyang Hu Ming Xia Miaoqing Zhao |
| author_sort | Xin Bing |
| collection | DOAJ |
| description | Hearing loss, as a sensory disorder, is the most common occurrence among humans, which has received increasing attention from society. It is mainly caused by the damage of inner ear hair cells (HCs) or the degeneration of spiral ganglion neurons. In mammals, cochlear HCs cannot regenerate naturally after injury, leading to irreversible hearing loss. Therefore, HCs are essential for hearing protection. In recent years, the protection of drug-related ototoxicity, inner ear stem cells, gene therapy, new materials, and signal regulation have become important ways to develop regeneration strategies of HCs. An in-depth study of the causes of the occurrence and development of hearing impairment and the regeneration of hearing loss for effective prevention, discovery, and treatment of deafness has great significance. This review aimed to analyze the development of the inner ear and summarize the related factors leading to HCs injury and the research progress of regeneration after injury. |
| format | Article |
| id | doaj-art-2ec9429d783b4271be7de592c5cf7881 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-2ec9429d783b4271be7de592c5cf78812025-01-29T05:02:33ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151203214Development of the inner ear and regeneration of hair cells after hearing impairmentXin Bing0Chengcheng Liu1Xue Cao2Chengzhilin Li3Xiaochen Gao4Fangyuan Zhu5Xinhao Wu6Na Guo7Houyang Hu8Ming Xia9Miaoqing Zhao10Department of Otolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, ChinaDepartment of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, ChinaDepartment of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Department of Otolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China; NHC Key Laboratory of Otorhinolaryngology, Jinan 250021, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271000, ChinaDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China; Corresponding author.Hearing loss, as a sensory disorder, is the most common occurrence among humans, which has received increasing attention from society. It is mainly caused by the damage of inner ear hair cells (HCs) or the degeneration of spiral ganglion neurons. In mammals, cochlear HCs cannot regenerate naturally after injury, leading to irreversible hearing loss. Therefore, HCs are essential for hearing protection. In recent years, the protection of drug-related ototoxicity, inner ear stem cells, gene therapy, new materials, and signal regulation have become important ways to develop regeneration strategies of HCs. An in-depth study of the causes of the occurrence and development of hearing impairment and the regeneration of hearing loss for effective prevention, discovery, and treatment of deafness has great significance. This review aimed to analyze the development of the inner ear and summarize the related factors leading to HCs injury and the research progress of regeneration after injury.http://www.sciencedirect.com/science/article/pii/S2667325823002935DevelopmentHearing impairmentHearing protectionInner ear hair cellsRegeneration |
| spellingShingle | Xin Bing Chengcheng Liu Xue Cao Chengzhilin Li Xiaochen Gao Fangyuan Zhu Xinhao Wu Na Guo Houyang Hu Ming Xia Miaoqing Zhao Development of the inner ear and regeneration of hair cells after hearing impairment Fundamental Research Development Hearing impairment Hearing protection Inner ear hair cells Regeneration |
| title | Development of the inner ear and regeneration of hair cells after hearing impairment |
| title_full | Development of the inner ear and regeneration of hair cells after hearing impairment |
| title_fullStr | Development of the inner ear and regeneration of hair cells after hearing impairment |
| title_full_unstemmed | Development of the inner ear and regeneration of hair cells after hearing impairment |
| title_short | Development of the inner ear and regeneration of hair cells after hearing impairment |
| title_sort | development of the inner ear and regeneration of hair cells after hearing impairment |
| topic | Development Hearing impairment Hearing protection Inner ear hair cells Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823002935 |
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