Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia
Abstract Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer’s Disease (AD) and Vascular Dementia (VD). By amino acid metabolomics, the concentrations of amino acids were dete...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Amino Acids |
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| Online Access: | https://doi.org/10.1007/s00726-024-03442-1 |
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| author | Xin Ma Xin-Meng Wang Guo-Zhang Tang Yi Wang Xue‑Chun Liu Shuai-Deng Wang Peng Peng Xiu-Hong Qi Xin-Ya Qin Yue‑Ju Wang Chen-Wei Wang Jiang-Ning Zhou |
| author_facet | Xin Ma Xin-Meng Wang Guo-Zhang Tang Yi Wang Xue‑Chun Liu Shuai-Deng Wang Peng Peng Xiu-Hong Qi Xin-Ya Qin Yue‑Ju Wang Chen-Wei Wang Jiang-Ning Zhou |
| author_sort | Xin Ma |
| collection | DOAJ |
| description | Abstract Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer’s Disease (AD) and Vascular Dementia (VD). By amino acid metabolomics, the concentrations of amino acids were determined in the serum of AD and VD patients as well as age-matched healthy controls. Several differences in the concentration of amino acids were observed in AD patients compared to both healthy controls and VD patients. However, no significant distinction was found between healthy controls and VD patients. Considering comorbidities, cystine levels were higher in AD than in VD among non-diabetic patients, but not in those with diabetes. Notably, creatine, spermidine, cystine, and tyrosine demonstrated favorable results in decision curve analyses and good discriminative performances, suggesting their potential for clinical application. These fundings give novel perspectives of serum amino acids for predicting metabolic pathways in AD and VD pathogenesis. |
| format | Article |
| id | doaj-art-2ebf9179f491459d9cfd1d73917d3ea8 |
| institution | Kabale University |
| issn | 1438-2199 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Amino Acids |
| spelling | doaj-art-2ebf9179f491459d9cfd1d73917d3ea82025-01-19T12:28:18ZengSpringerAmino Acids1438-21992025-01-0157111610.1007/s00726-024-03442-1Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular DementiaXin Ma0Xin-Meng Wang1Guo-Zhang Tang2Yi Wang3Xue‑Chun Liu4Shuai-Deng Wang5Peng Peng6Xiu-Hong Qi7Xin-Ya Qin8Yue‑Ju Wang9Chen-Wei Wang10Jiang-Ning Zhou11School of Basic Medical Sciences, Anhui Medical UniversityDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical UniversitySchool of Basic Medical Sciences, Anhui Medical UniversitySchool of Basic Medical Sciences, Anhui Medical UniversityDepartment of Neurology, Hefei Hospital Affiliated to Anhui Medical UniversitySchool of Basic Medical Sciences, Anhui Medical UniversitySchool of Basic Medical Sciences, Anhui Medical UniversityInstitute of Artificial Intelligence, Hefei Comprehensive National Science CenterInstitute of Artificial Intelligence, Hefei Comprehensive National Science CenterDepartment of Geriatrics, The First Affiliated Hospital of Soochow UniversitySchool of Basic Medical Sciences, Anhui Medical UniversityInstitute of Brain Science, The First Affiliated Hospital of Anhui Medical UniversityAbstract Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer’s Disease (AD) and Vascular Dementia (VD). By amino acid metabolomics, the concentrations of amino acids were determined in the serum of AD and VD patients as well as age-matched healthy controls. Several differences in the concentration of amino acids were observed in AD patients compared to both healthy controls and VD patients. However, no significant distinction was found between healthy controls and VD patients. Considering comorbidities, cystine levels were higher in AD than in VD among non-diabetic patients, but not in those with diabetes. Notably, creatine, spermidine, cystine, and tyrosine demonstrated favorable results in decision curve analyses and good discriminative performances, suggesting their potential for clinical application. These fundings give novel perspectives of serum amino acids for predicting metabolic pathways in AD and VD pathogenesis.https://doi.org/10.1007/s00726-024-03442-1Alzheimer’s DiseaseVascular DementiaBiomarkerTargeted metabolomicAmino acids |
| spellingShingle | Xin Ma Xin-Meng Wang Guo-Zhang Tang Yi Wang Xue‑Chun Liu Shuai-Deng Wang Peng Peng Xiu-Hong Qi Xin-Ya Qin Yue‑Ju Wang Chen-Wei Wang Jiang-Ning Zhou Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia Amino Acids Alzheimer’s Disease Vascular Dementia Biomarker Targeted metabolomic Amino acids |
| title | Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia |
| title_full | Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia |
| title_fullStr | Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia |
| title_full_unstemmed | Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia |
| title_short | Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia |
| title_sort | alterations of amino acids in older adults with alzheimer s disease and vascular dementia |
| topic | Alzheimer’s Disease Vascular Dementia Biomarker Targeted metabolomic Amino acids |
| url | https://doi.org/10.1007/s00726-024-03442-1 |
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