Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease
BackgroundParkinson’s disease (PD) is the second most prevalent neurological disorder, characterized by motor symptoms such as tremor and rigidity due to the degeneration of dopaminergic neurons in the substantia nigra. This study investigates the formulation of quercetin, a natural bioflavonoid wit...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1519649/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584983048355840 |
|---|---|
| author | Abhishek A. Revankar Archana S. Patil Reshma Karishetti Krutuja R. Chougule Priyanka Patil Abhijit Salokhe |
| author_facet | Abhishek A. Revankar Archana S. Patil Reshma Karishetti Krutuja R. Chougule Priyanka Patil Abhijit Salokhe |
| author_sort | Abhishek A. Revankar |
| collection | DOAJ |
| description | BackgroundParkinson’s disease (PD) is the second most prevalent neurological disorder, characterized by motor symptoms such as tremor and rigidity due to the degeneration of dopaminergic neurons in the substantia nigra. This study investigates the formulation of quercetin, a natural bioflavonoid with potent antioxidant and anti-inflammatory properties, as niosomes for intranasal delivery to enhance its bioavailability and therapeutic potential for PD.MethodsThe niosomal formulation was optimized for critical parameters including particle size, entrapment efficiency, and zeta potential. Male Wistar rats were utilized to assess the effects of quercetin-loaded niosomes on motor function, dopaminergic neuron protection, and oxidative stress alleviation.ResultsThe optimized niosomal formulation exhibited a particle size of 195 nm, a polydispersity index (PDI) of 0.29, a zeta potential (ZP) of −30.63 mV, and an entrapment efficiency (EE) of 82.77%. In vivo evaluations conducted using the haloperidol-induced PD model revealed significant enhancements in behavioural, biochemical, and histopathological outcomes when compared to both disease controls and the standard treatment group. Additionally, short-term stability tests confirmed the robustness of the formulation.ConclusionThe findings suggest that the quercetin-loaded niosomal formulation offers improved drug delivery and efficacy, indicating its potential as a superior treatment option for PD compared to conventional dosage forms. This approach may pave the way for enhanced therapeutic strategies targeting the neurodegenerative processes underlying Parkinson’s disease. |
| format | Article |
| id | doaj-art-2eb77bd64878419d9b18ba548268b3aa |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-2eb77bd64878419d9b18ba548268b3aa2025-01-27T06:41:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15196491519649Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s diseaseAbhishek A. Revankar0Archana S. Patil1Reshma Karishetti2Krutuja R. Chougule3Priyanka Patil4Abhijit Salokhe5Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaDepartment of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaDepartment of pathology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaDepartment of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaDepartment of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaDepartment of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, IndiaBackgroundParkinson’s disease (PD) is the second most prevalent neurological disorder, characterized by motor symptoms such as tremor and rigidity due to the degeneration of dopaminergic neurons in the substantia nigra. This study investigates the formulation of quercetin, a natural bioflavonoid with potent antioxidant and anti-inflammatory properties, as niosomes for intranasal delivery to enhance its bioavailability and therapeutic potential for PD.MethodsThe niosomal formulation was optimized for critical parameters including particle size, entrapment efficiency, and zeta potential. Male Wistar rats were utilized to assess the effects of quercetin-loaded niosomes on motor function, dopaminergic neuron protection, and oxidative stress alleviation.ResultsThe optimized niosomal formulation exhibited a particle size of 195 nm, a polydispersity index (PDI) of 0.29, a zeta potential (ZP) of −30.63 mV, and an entrapment efficiency (EE) of 82.77%. In vivo evaluations conducted using the haloperidol-induced PD model revealed significant enhancements in behavioural, biochemical, and histopathological outcomes when compared to both disease controls and the standard treatment group. Additionally, short-term stability tests confirmed the robustness of the formulation.ConclusionThe findings suggest that the quercetin-loaded niosomal formulation offers improved drug delivery and efficacy, indicating its potential as a superior treatment option for PD compared to conventional dosage forms. This approach may pave the way for enhanced therapeutic strategies targeting the neurodegenerative processes underlying Parkinson’s disease.https://www.frontiersin.org/articles/10.3389/fphar.2024.1519649/fullbiochemical assayintranasalniosomesParkinson diseasequercetin |
| spellingShingle | Abhishek A. Revankar Archana S. Patil Reshma Karishetti Krutuja R. Chougule Priyanka Patil Abhijit Salokhe Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease Frontiers in Pharmacology biochemical assay intranasal niosomes Parkinson disease quercetin |
| title | Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease |
| title_full | Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease |
| title_fullStr | Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease |
| title_full_unstemmed | Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease |
| title_short | Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease |
| title_sort | enhanced bioavailability of quercetin loaded niosomal in situ gel for the management of parkinson s disease |
| topic | biochemical assay intranasal niosomes Parkinson disease quercetin |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1519649/full |
| work_keys_str_mv | AT abhishekarevankar enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease AT archanaspatil enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease AT reshmakarishetti enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease AT krutujarchougule enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease AT priyankapatil enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease AT abhijitsalokhe enhancedbioavailabilityofquercetinloadedniosomalinsitugelforthemanagementofparkinsonsdisease |