Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation
Primary bone marrow diffuse large B-cell lymphoma is an exceedingly rare form of non-Hodgkin lymphoma. It may demonstrate a leukemic presentation, and a proportion of cases have CD5 expression. The prognostic implications of this CD5-positivity remain unknown. Here, we present a 78-year-old man who...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/2628100 |
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| author | Mark G. Evans Sherif A. Rezk Lauren C. Pinter-Brown Xiaohui Zhao |
| author_facet | Mark G. Evans Sherif A. Rezk Lauren C. Pinter-Brown Xiaohui Zhao |
| author_sort | Mark G. Evans |
| collection | DOAJ |
| description | Primary bone marrow diffuse large B-cell lymphoma is an exceedingly rare form of non-Hodgkin lymphoma. It may demonstrate a leukemic presentation, and a proportion of cases have CD5 expression. The prognostic implications of this CD5-positivity remain unknown. Here, we present a 78-year-old man who presented with circulating peripheral blood lymphoma cells and a hypercellular marrow involved by diffuse large B-cell lymphoma, germinal center B-cell subtype. The patient responded favorably to six cycles of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) and intrathecal methotrexate. He unfortunately relapsed in several enlarged inguinal lymph nodes and succumbed to the lymphoma approximately one year after diagnosis, demonstrating the particularly aggressive clinical course of his disease. |
| format | Article |
| id | doaj-art-2eaa9b81104a456f82b11a30c29d6413 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-2eaa9b81104a456f82b11a30c29d64132025-02-03T01:08:51ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/26281002628100Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic PresentationMark G. Evans0Sherif A. Rezk1Lauren C. Pinter-Brown2Xiaohui Zhao3Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, CA, USADepartment of Medicine, Division of Hematology/Oncology, University of California Irvine (UCI) Medical Center, Orange, CA, USADepartment of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, CA, USAPrimary bone marrow diffuse large B-cell lymphoma is an exceedingly rare form of non-Hodgkin lymphoma. It may demonstrate a leukemic presentation, and a proportion of cases have CD5 expression. The prognostic implications of this CD5-positivity remain unknown. Here, we present a 78-year-old man who presented with circulating peripheral blood lymphoma cells and a hypercellular marrow involved by diffuse large B-cell lymphoma, germinal center B-cell subtype. The patient responded favorably to six cycles of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) and intrathecal methotrexate. He unfortunately relapsed in several enlarged inguinal lymph nodes and succumbed to the lymphoma approximately one year after diagnosis, demonstrating the particularly aggressive clinical course of his disease.http://dx.doi.org/10.1155/2021/2628100 |
| spellingShingle | Mark G. Evans Sherif A. Rezk Lauren C. Pinter-Brown Xiaohui Zhao Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation Case Reports in Hematology |
| title | Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation |
| title_full | Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation |
| title_fullStr | Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation |
| title_full_unstemmed | Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation |
| title_short | Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation |
| title_sort | aggressive cd5 positive primary bone marrow diffuse large b cell lymphoma with leukemic presentation |
| url | http://dx.doi.org/10.1155/2021/2628100 |
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