New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study
Background. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD. Objective. The aim of the present study was to establish the links b...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2015/283021 |
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| author | Hayder M. Alkuraishy Ali I. Al-Gareeb |
| author_facet | Hayder M. Alkuraishy Ali I. Al-Gareeb |
| author_sort | Hayder M. Alkuraishy |
| collection | DOAJ |
| description | Background. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD. Objective. The aim of the present study was to establish the links between omentin-1 and acute myocardial infarction in metformin patients. Subjects and Methods. A cross-sectional study was performed on eighty-five patients with type II DM and acute MI. They are divided as follows: Group I, 62 patients with type II DM who received metformin prior to onset of acute MI; Group II, 23 patients with type II DM who did not receive metformin prior to onset of acute MI; and Group III, 30 normal healthy controls. Venous blood was drawn from each participant for determination of lipid profile, plasma omentin-1, cardiac troponin-I (cTn-I) and other routine tests. Results. Patients that presented with acute MI that received metformin show a significant difference in all biochemical parameters (p<0.001); metformin increases serum omentin-1 level and decreases serum cardiac troponin-I level compared with control subjects and nonmetformin treated patients. Conclusion. Metformin pharmacotherapy increases omentin-1 serum levels and may be regarded as a potential agent in the prevention of the occurrences of acute MI in diabetic patients. |
| format | Article |
| id | doaj-art-2ea3579e750a41729f6c733611ea6f1e |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-2ea3579e750a41729f6c733611ea6f1e2025-02-03T05:45:24ZengWileyEmergency Medicine International2090-28402090-28592015-01-01201510.1155/2015/283021283021New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional StudyHayder M. Alkuraishy0Ali I. Al-Gareeb1Department of Clinical Pharmacology and Therapeutic, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, IraqDepartment of Clinical Pharmacology and Therapeutic, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, IraqBackground. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD. Objective. The aim of the present study was to establish the links between omentin-1 and acute myocardial infarction in metformin patients. Subjects and Methods. A cross-sectional study was performed on eighty-five patients with type II DM and acute MI. They are divided as follows: Group I, 62 patients with type II DM who received metformin prior to onset of acute MI; Group II, 23 patients with type II DM who did not receive metformin prior to onset of acute MI; and Group III, 30 normal healthy controls. Venous blood was drawn from each participant for determination of lipid profile, plasma omentin-1, cardiac troponin-I (cTn-I) and other routine tests. Results. Patients that presented with acute MI that received metformin show a significant difference in all biochemical parameters (p<0.001); metformin increases serum omentin-1 level and decreases serum cardiac troponin-I level compared with control subjects and nonmetformin treated patients. Conclusion. Metformin pharmacotherapy increases omentin-1 serum levels and may be regarded as a potential agent in the prevention of the occurrences of acute MI in diabetic patients.http://dx.doi.org/10.1155/2015/283021 |
| spellingShingle | Hayder M. Alkuraishy Ali I. Al-Gareeb New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study Emergency Medicine International |
| title | New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study |
| title_full | New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study |
| title_fullStr | New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study |
| title_full_unstemmed | New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study |
| title_short | New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study |
| title_sort | new insights into the role of metformin effects on serum omentin 1 levels in acute myocardial infarction cross sectional study |
| url | http://dx.doi.org/10.1155/2015/283021 |
| work_keys_str_mv | AT haydermalkuraishy newinsightsintotheroleofmetformineffectsonserumomentin1levelsinacutemyocardialinfarctioncrosssectionalstudy AT aliialgareeb newinsightsintotheroleofmetformineffectsonserumomentin1levelsinacutemyocardialinfarctioncrosssectionalstudy |