Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea
Abstract There is limited data on the risk of second primary malignancies (SPMs) in Asian melanoma survivors. This study aimed to identify the risk of SPMs in Asian melanoma survivors. Standardized incidence ratios (SIRs) were calculated for overall and specific SPMs. The risk factor for overall SPM...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87838-3 |
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| author | Joon Min Jung Do Hyung Kim Ye-Jee Kim Ik Jun Moon Woo Jin Lee Sung Eun Chang Mi Woo Lee Chong Hyun Won |
| author_facet | Joon Min Jung Do Hyung Kim Ye-Jee Kim Ik Jun Moon Woo Jin Lee Sung Eun Chang Mi Woo Lee Chong Hyun Won |
| author_sort | Joon Min Jung |
| collection | DOAJ |
| description | Abstract There is limited data on the risk of second primary malignancies (SPMs) in Asian melanoma survivors. This study aimed to identify the risk of SPMs in Asian melanoma survivors. Standardized incidence ratios (SIRs) were calculated for overall and specific SPMs. The risk factor for overall SPM development was analyzed using a multivariable Cox regression model. A total of 10,070 patients with melanoma were included in the study. Melanoma survivors exhibited an increased risk of overall SPM (SIR, 1.51; 95% confidence interval [CI], 1.34–1.70). Additionally, specific SPMs were more common among melanoma survivors, including nonmelanoma skin cancer, oral cavity and pharyngeal cancer, renal cancer, female breast cancer, lung cancer, pancreatic cancer, and liver cancer. Independent risk factors for overall SPM development included a Charlson Comorbidity Index ≥ 1 (adjusted hazard ratio [aHR], 1.41; 95% CI, 1.07–1.87), and a body mass index ≥ 25 kg/m2 (aHR, 1.47; 95% CI, 1.04–2.08). Inherent uncertainty related to diagnostic codes may exist. The risk of overall and specific SPMs was significantly elevated in Asian melanoma survivors, particularly among those with invasive melanoma. Among modifiable factors, a high body mass index (BMI) was associated with an increased risk of SPM. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-2e9e9b78072246488085ba14a01e652f2025-02-02T12:23:09ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-87838-3Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of KoreaJoon Min Jung0Do Hyung Kim1Ye-Jee Kim2Ik Jun Moon3Woo Jin Lee4Sung Eun Chang5Mi Woo Lee6Chong Hyun Won7Department of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Dermatology, Asan Medical Center, University of Ulsan College of MedicineAbstract There is limited data on the risk of second primary malignancies (SPMs) in Asian melanoma survivors. This study aimed to identify the risk of SPMs in Asian melanoma survivors. Standardized incidence ratios (SIRs) were calculated for overall and specific SPMs. The risk factor for overall SPM development was analyzed using a multivariable Cox regression model. A total of 10,070 patients with melanoma were included in the study. Melanoma survivors exhibited an increased risk of overall SPM (SIR, 1.51; 95% confidence interval [CI], 1.34–1.70). Additionally, specific SPMs were more common among melanoma survivors, including nonmelanoma skin cancer, oral cavity and pharyngeal cancer, renal cancer, female breast cancer, lung cancer, pancreatic cancer, and liver cancer. Independent risk factors for overall SPM development included a Charlson Comorbidity Index ≥ 1 (adjusted hazard ratio [aHR], 1.41; 95% CI, 1.07–1.87), and a body mass index ≥ 25 kg/m2 (aHR, 1.47; 95% CI, 1.04–2.08). Inherent uncertainty related to diagnostic codes may exist. The risk of overall and specific SPMs was significantly elevated in Asian melanoma survivors, particularly among those with invasive melanoma. Among modifiable factors, a high body mass index (BMI) was associated with an increased risk of SPM.https://doi.org/10.1038/s41598-025-87838-3MelanomaMelanoma in situCancer |
| spellingShingle | Joon Min Jung Do Hyung Kim Ye-Jee Kim Ik Jun Moon Woo Jin Lee Sung Eun Chang Mi Woo Lee Chong Hyun Won Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea Scientific Reports Melanoma Melanoma in situ Cancer |
| title | Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea |
| title_full | Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea |
| title_fullStr | Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea |
| title_full_unstemmed | Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea |
| title_short | Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea |
| title_sort | risk of second primary malignancies among survivors of cutaneous melanoma a nationwide population based study in the republic of korea |
| topic | Melanoma Melanoma in situ Cancer |
| url | https://doi.org/10.1038/s41598-025-87838-3 |
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