Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
The late endo-/lysosomal P-type ATPase ATP13A2 (PARK9) is implicated in Parkinson’s disease (PD) and Kufor-Rakeb syndrome, early-onset atypical Parkinsonism. ATP13A2 interacts at the N-terminus with the signaling lipids phosphatidic acid (PA) and phosphatidylinositol (3,5) bisphosphate (PI(3,5)P2),...
Saved in:
Main Authors: | Shaun Martin, Sarah van Veen, Tine Holemans, Seyma Demirsoy, Chris van den Haute, Veerle Baekelandt, Patrizia Agostinis, Jan Eggermont, Peter Vangheluwe |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2016-01-01
|
Series: | Parkinson's Disease |
Online Access: | http://dx.doi.org/10.1155/2016/9531917 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
by: Géraldine Gelders, et al.
Published: (2018-01-01) -
Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter
by: Parveen Goyal, et al.
Published: (2025-02-01) -
ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action
by: Jeong-Oog Lee, et al.
Published: (2015-01-01) -
ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
by: Li Pang, et al.
Published: (2014-01-01) -
Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis
by: Yan Lin, et al.
Published: (2021-01-01)