Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin
Aims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels. Methods. We performed a retrospective study of 119 patients without diabetes who received...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/436725 |
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| author | Kazuaki Tokodai Noritoshi Amada Izumi Haga Atsushi Nakamura Toshiaki Kashiwadate Naoki Kawagishi Noriaki Ohuchi |
| author_facet | Kazuaki Tokodai Noritoshi Amada Izumi Haga Atsushi Nakamura Toshiaki Kashiwadate Naoki Kawagishi Noriaki Ohuchi |
| author_sort | Kazuaki Tokodai |
| collection | DOAJ |
| description | Aims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels.
Methods. We performed a retrospective study of 119 patients without diabetes who received kidney transplantation between March 2000 and January 2012. Univariate and multivariate logistic regression analyses were used to investigate the association of several parameters with NODAT. Predictive discrimination of HbA1c was assessed using a receiver-operating characteristic curve. Results. Seventeen patients (14.3%) developed NODAT within 1 year of transplantation. Univariate logistic regression analysis revealed that recipient age, gender, and HbA1c were predictors of NODAT. In the multivariate analysis, the association between pretransplant HbA1c and NODAT development did not reach statistical significance (P=0.07). To avoid the strong influence of high-dose erythropoietin on HbA1c levels, we performed subgroup analyses on 85 patients receiving no or low-dose (≤6000 IU/week) erythropoietin. HbA1c was again an independent predictor for NODAT. Receiver-operating characteristic analysis revealed a cut-off value of 5.2% with an optimal sensitivity of 64% and specificity of 78% for predicting NODAT. Conclusions. Our results reveal that the pretransplant HbA1c level is a useful predictor for NODAT in patients receiving no or low-dose erythropoietin. |
| format | Article |
| id | doaj-art-2e8f0706589a4fd2bb782bff40287e1a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2e8f0706589a4fd2bb782bff40287e1a2025-02-03T06:08:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/436725436725Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose ErythropoietinKazuaki Tokodai0Noritoshi Amada1Izumi Haga2Atsushi Nakamura3Toshiaki Kashiwadate4Naoki Kawagishi5Noriaki Ohuchi6Department of Surgery, Sendai Shakaihoken Hospital, Sendai 980-8574, JapanDepartment of Surgery, Sendai Shakaihoken Hospital, Sendai 980-8574, JapanDepartment of Surgery, Sendai Shakaihoken Hospital, Sendai 980-8574, JapanDepartment of Surgery, Sendai Shakaihoken Hospital, Sendai 980-8574, JapanDepartment of Surgery, Sendai Shakaihoken Hospital, Sendai 980-8574, JapanDivision of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanDivision of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanAims. To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels. Methods. We performed a retrospective study of 119 patients without diabetes who received kidney transplantation between March 2000 and January 2012. Univariate and multivariate logistic regression analyses were used to investigate the association of several parameters with NODAT. Predictive discrimination of HbA1c was assessed using a receiver-operating characteristic curve. Results. Seventeen patients (14.3%) developed NODAT within 1 year of transplantation. Univariate logistic regression analysis revealed that recipient age, gender, and HbA1c were predictors of NODAT. In the multivariate analysis, the association between pretransplant HbA1c and NODAT development did not reach statistical significance (P=0.07). To avoid the strong influence of high-dose erythropoietin on HbA1c levels, we performed subgroup analyses on 85 patients receiving no or low-dose (≤6000 IU/week) erythropoietin. HbA1c was again an independent predictor for NODAT. Receiver-operating characteristic analysis revealed a cut-off value of 5.2% with an optimal sensitivity of 64% and specificity of 78% for predicting NODAT. Conclusions. Our results reveal that the pretransplant HbA1c level is a useful predictor for NODAT in patients receiving no or low-dose erythropoietin.http://dx.doi.org/10.1155/2014/436725 |
| spellingShingle | Kazuaki Tokodai Noritoshi Amada Izumi Haga Atsushi Nakamura Toshiaki Kashiwadate Naoki Kawagishi Noriaki Ohuchi Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin International Journal of Endocrinology |
| title | Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin |
| title_full | Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin |
| title_fullStr | Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin |
| title_full_unstemmed | Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin |
| title_short | Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin |
| title_sort | pretransplant hba1c is a useful predictor for the development of new onset diabetes in renal transplant recipients receiving no or low dose erythropoietin |
| url | http://dx.doi.org/10.1155/2014/436725 |
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