A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole
Cephalosporins are one of the most commonly used first-line antibiotics. In this report, we describe the case of a patient who developed alveolar bleeding due to clotting abnormality following the use of cefmetazole, one of cephalosporins containing an N-methylthiotetrazole (NMTT) side chain. Compar...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3574064 |
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| author | Eri Nakano Tsubasa Fukuoka Nao Takeuchi Tomoyuki Seki Michihiro Tamai Makoto Araki |
| author_facet | Eri Nakano Tsubasa Fukuoka Nao Takeuchi Tomoyuki Seki Michihiro Tamai Makoto Araki |
| author_sort | Eri Nakano |
| collection | DOAJ |
| description | Cephalosporins are one of the most commonly used first-line antibiotics. In this report, we describe the case of a patient who developed alveolar bleeding due to clotting abnormality following the use of cefmetazole, one of cephalosporins containing an N-methylthiotetrazole (NMTT) side chain. Compared to other antibiotics, cephalosporins with an NMTT side chain cause a higher degree of bleeding events. The bleeding tendency is caused by the depletion of vitamin K-dependent clotting factors via inhibition of the vitamin K epoxide reductase. This mechanism of action is the same as warfarin. Recent years have seen an increase in the number of patients using direct oral anticoagulants that do not require coagulation tests. As a consequence, there may be an increase in the number of bleeding events due to anticoagulant drugs and such antibiotics coprescription. Therefore, this case is an instructive lesson. |
| format | Article |
| id | doaj-art-2e81c2dea5c34aa4be78eb5fc414b3a1 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-2e81c2dea5c34aa4be78eb5fc414b3a12025-02-03T06:10:53ZengWileyCase Reports in Medicine1687-96271687-96352019-01-01201910.1155/2019/35740643574064A Case of Alveolar Bleeding from Clotting Abnormality by CefmetazoleEri Nakano0Tsubasa Fukuoka1Nao Takeuchi2Tomoyuki Seki3Michihiro Tamai4Makoto Araki5Department of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano, JapanCephalosporins are one of the most commonly used first-line antibiotics. In this report, we describe the case of a patient who developed alveolar bleeding due to clotting abnormality following the use of cefmetazole, one of cephalosporins containing an N-methylthiotetrazole (NMTT) side chain. Compared to other antibiotics, cephalosporins with an NMTT side chain cause a higher degree of bleeding events. The bleeding tendency is caused by the depletion of vitamin K-dependent clotting factors via inhibition of the vitamin K epoxide reductase. This mechanism of action is the same as warfarin. Recent years have seen an increase in the number of patients using direct oral anticoagulants that do not require coagulation tests. As a consequence, there may be an increase in the number of bleeding events due to anticoagulant drugs and such antibiotics coprescription. Therefore, this case is an instructive lesson.http://dx.doi.org/10.1155/2019/3574064 |
| spellingShingle | Eri Nakano Tsubasa Fukuoka Nao Takeuchi Tomoyuki Seki Michihiro Tamai Makoto Araki A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole Case Reports in Medicine |
| title | A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole |
| title_full | A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole |
| title_fullStr | A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole |
| title_full_unstemmed | A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole |
| title_short | A Case of Alveolar Bleeding from Clotting Abnormality by Cefmetazole |
| title_sort | case of alveolar bleeding from clotting abnormality by cefmetazole |
| url | http://dx.doi.org/10.1155/2019/3574064 |
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