The burden of appendicitis and surgical site infection of appendectomy worldwide
Introduction: Appendicitis is a global abdominal disease and is often treated by appendectomy. Surgical site infection (SSI) is a common complication after an appendectomy that causes a significant burden on health systems. This study aimed to evaluate the trends and variations in the burden of app...
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The Journal of Infection in Developing Countries
2023-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17145 |
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| author | Lin Yang Rongshou Zheng Hong Li Yan Ren Hui Chen |
| author_facet | Lin Yang Rongshou Zheng Hong Li Yan Ren Hui Chen |
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Introduction: Appendicitis is a global abdominal disease and is often treated by appendectomy. Surgical site infection (SSI) is a common complication after an appendectomy that causes a significant burden on health systems. This study aimed to evaluate the trends and variations in the burden of appendicitis by year, region, socioeconomic status, and health expenditure and to assess associated SSI by appendicitis burden, surgical approach, and type of appendicitis.
Methodology: Data on Disability-Adjusted Life Years (DALYs) and the human development index were collected from the Global Burden of Disease (GBD) Study and the United Nations Development Programme, respectively. Studies on SSI after appendectomy using the uniform definition and published in 1990-2021 were retrieved.
Results: Between 1990 and 2019, the global age-standardized DALY rate of appendicitis decreased by 53.14%, with the highest burdens in Latin America and Africa. The burden of appendicitis was significantly negatively correlated with HDI (r = -0.743, p<0.001) and health expenditure (r = -0.287, p<0.001). Among 320 published studies on SSI after an appendectomy, 78.44% of studies did not report criteria for SSI diagnosis or adopt a uniform definition. In total, 69 studies with uniform SSI definitions were included. Studies with uniform SSI definitions were recorded poorly in regions with a heavy burden of appendicitis. The SSI of appendectomy was positively correlated with open appendectomy and complicated appendicitis.
Conclusions: Uniform SSI definition, promotion of laparoscopic technology, and establishment of SSI special management are needed to decrease the burden of SSI after an appendectomy, especially in developing countries.
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| format | Article |
| id | doaj-art-2e76f37122994a8fbb71f478e5b59a2c |
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| issn | 1972-2680 |
| language | English |
| publishDate | 2023-03-01 |
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| spelling | doaj-art-2e76f37122994a8fbb71f478e5b59a2c2025-08-20T02:27:19ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-03-01170310.3855/jidc.17145The burden of appendicitis and surgical site infection of appendectomy worldwideLin Yang0Rongshou Zheng1Hong Li2Yan Ren3Hui Chen4Department of Hospital-Acquired Infection Control, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, ChinaNational Central Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Hospital-Acquired Infection Control, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, ChinaDepartment of Hospital-Acquired Infection Control, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, ChinaDepartment of Hospital-Acquired Infection Control, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, China Introduction: Appendicitis is a global abdominal disease and is often treated by appendectomy. Surgical site infection (SSI) is a common complication after an appendectomy that causes a significant burden on health systems. This study aimed to evaluate the trends and variations in the burden of appendicitis by year, region, socioeconomic status, and health expenditure and to assess associated SSI by appendicitis burden, surgical approach, and type of appendicitis. Methodology: Data on Disability-Adjusted Life Years (DALYs) and the human development index were collected from the Global Burden of Disease (GBD) Study and the United Nations Development Programme, respectively. Studies on SSI after appendectomy using the uniform definition and published in 1990-2021 were retrieved. Results: Between 1990 and 2019, the global age-standardized DALY rate of appendicitis decreased by 53.14%, with the highest burdens in Latin America and Africa. The burden of appendicitis was significantly negatively correlated with HDI (r = -0.743, p<0.001) and health expenditure (r = -0.287, p<0.001). Among 320 published studies on SSI after an appendectomy, 78.44% of studies did not report criteria for SSI diagnosis or adopt a uniform definition. In total, 69 studies with uniform SSI definitions were included. Studies with uniform SSI definitions were recorded poorly in regions with a heavy burden of appendicitis. The SSI of appendectomy was positively correlated with open appendectomy and complicated appendicitis. Conclusions: Uniform SSI definition, promotion of laparoscopic technology, and establishment of SSI special management are needed to decrease the burden of SSI after an appendectomy, especially in developing countries. https://jidc.org/index.php/journal/article/view/17145Appendicitisdisability-adjusted life yearsglobal burden of diseasesurgical site infectioninfection control |
| spellingShingle | Lin Yang Rongshou Zheng Hong Li Yan Ren Hui Chen The burden of appendicitis and surgical site infection of appendectomy worldwide Journal of Infection in Developing Countries Appendicitis disability-adjusted life years global burden of disease surgical site infection infection control |
| title | The burden of appendicitis and surgical site infection of appendectomy worldwide |
| title_full | The burden of appendicitis and surgical site infection of appendectomy worldwide |
| title_fullStr | The burden of appendicitis and surgical site infection of appendectomy worldwide |
| title_full_unstemmed | The burden of appendicitis and surgical site infection of appendectomy worldwide |
| title_short | The burden of appendicitis and surgical site infection of appendectomy worldwide |
| title_sort | burden of appendicitis and surgical site infection of appendectomy worldwide |
| topic | Appendicitis disability-adjusted life years global burden of disease surgical site infection infection control |
| url | https://jidc.org/index.php/journal/article/view/17145 |
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