Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults
Abstract Introduction: Black and Latino individuals are underrepresented in COVID-19 treatment and vaccine clinical trials, calling for an examination of factors that may predict willingness to participate in trials. Methods: We administered the Common Survey 2.0 developed by the Community Engag...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Journal of Clinical and Translational Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S205986612400654X/type/journal_article |
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| author | Christine M. Weston Elizabeth L. Andrade Wuraola Olawole Monica Guerrero Vazquez Hailey Miller Sarah C. Stevens Cyd Lacanienta Nancy Perrin Mark C. Edberg Thomas A. Mellman Yvonne Bronner Roger Clark Cheryl R. Dennison Himmelfarb |
| author_facet | Christine M. Weston Elizabeth L. Andrade Wuraola Olawole Monica Guerrero Vazquez Hailey Miller Sarah C. Stevens Cyd Lacanienta Nancy Perrin Mark C. Edberg Thomas A. Mellman Yvonne Bronner Roger Clark Cheryl R. Dennison Himmelfarb |
| author_sort | Christine M. Weston |
| collection | DOAJ |
| description |
Abstract
Introduction:
Black and Latino individuals are underrepresented in COVID-19 treatment and vaccine clinical trials, calling for an examination of factors that may predict willingness to participate in trials.
Methods:
We administered the Common Survey 2.0 developed by the Community Engagement Alliance (CEAL) Against COVID-19 Disparities to 600 Black and Latino adults in Baltimore City, Prince George’s County, Maryland, Montgomery County, Maryland, and Washington, DC, between October and December 2021. We examined the relationship between awareness of clinical trials, social determinants of health challenges, trust in COVID-19 clinical trial information sources, and willingness to participate in COVID-19 treatment and vaccine trials using multinomial regression analysis.
Results:
Approximately half of Black and Latino respondents were unwilling to participate in COVID-19 treatment or vaccine clinical trials. Results showed that increased trust in COVID-19 clinical trial information sources and trial awareness were associated with greater willingness to participate in COVID-19 treatment and vaccine trials among Black and Latino individuals. For Latino respondents, having recently experienced more challenges related to social determinants of health was associated with a decreased likelihood of willingness to participate in COVID-19 vaccine trials.
Conclusions:
The willingness of Black and Latino adults to participate in COVID-19 treatment and vaccine clinical trials is influenced by trial awareness and trust in trial information sources. Ensuring the inclusion of these communities in clinical trials will require approaches that build greater awareness and trust.
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| format | Article |
| id | doaj-art-2e6abea3f33c4eec8a5b9ce40ed02833 |
| institution | OA Journals |
| issn | 2059-8661 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj-art-2e6abea3f33c4eec8a5b9ce40ed028332025-08-20T02:36:20ZengCambridge University PressJournal of Clinical and Translational Science2059-86612024-01-01810.1017/cts.2024.654Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adultsChristine M. Weston0https://orcid.org/0009-0003-6212-1086Elizabeth L. Andrade1Wuraola Olawole2Monica Guerrero Vazquez3Hailey Miller4Sarah C. Stevens5https://orcid.org/0000-0002-7599-0729Cyd Lacanienta6https://orcid.org/0000-0002-3840-0822Nancy Perrin7Mark C. Edberg8Thomas A. Mellman9Yvonne Bronner10Roger Clark11Cheryl R. Dennison Himmelfarb12Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAGeorge Washington University Milken Institute School of Public Health, Washingon, DC, USAJohns Hopkins University School of Nursing, Baltimore, MD, USAJohns Hopkins University Centro SOL, Baltimore, MD, USA Johns Hopkins University School of Medicine, Baltimore, MD, USAJohns Hopkins University School of Nursing, Baltimore, MD, USAJohns Hopkins University Institute for Clinical and Translational Research, Baltimore, MD, USAJohns Hopkins University Institute for Clinical and Translational Research, Baltimore, MD, USAHoward University, Washington, DC, USAGeorge Washington University Milken Institute School of Public Health, Washingon, DC, USAHoward University, Washington, DC, USAMorgan State University, Baltimore, MD, USAJohns Hopkins University Institute for Clinical and Translational Research, Baltimore, MD, USAJohns Hopkins University School of Nursing, Baltimore, MD, USA Johns Hopkins University School of Medicine, Baltimore, MD, USA Johns Hopkins University Institute for Clinical and Translational Research, Baltimore, MD, USA Abstract Introduction: Black and Latino individuals are underrepresented in COVID-19 treatment and vaccine clinical trials, calling for an examination of factors that may predict willingness to participate in trials. Methods: We administered the Common Survey 2.0 developed by the Community Engagement Alliance (CEAL) Against COVID-19 Disparities to 600 Black and Latino adults in Baltimore City, Prince George’s County, Maryland, Montgomery County, Maryland, and Washington, DC, between October and December 2021. We examined the relationship between awareness of clinical trials, social determinants of health challenges, trust in COVID-19 clinical trial information sources, and willingness to participate in COVID-19 treatment and vaccine trials using multinomial regression analysis. Results: Approximately half of Black and Latino respondents were unwilling to participate in COVID-19 treatment or vaccine clinical trials. Results showed that increased trust in COVID-19 clinical trial information sources and trial awareness were associated with greater willingness to participate in COVID-19 treatment and vaccine trials among Black and Latino individuals. For Latino respondents, having recently experienced more challenges related to social determinants of health was associated with a decreased likelihood of willingness to participate in COVID-19 vaccine trials. Conclusions: The willingness of Black and Latino adults to participate in COVID-19 treatment and vaccine clinical trials is influenced by trial awareness and trust in trial information sources. Ensuring the inclusion of these communities in clinical trials will require approaches that build greater awareness and trust. https://www.cambridge.org/core/product/identifier/S205986612400654X/type/journal_articleCOVID-19clinical trial participationAfrican Americans/BlacksLatinossocial determinants of health |
| spellingShingle | Christine M. Weston Elizabeth L. Andrade Wuraola Olawole Monica Guerrero Vazquez Hailey Miller Sarah C. Stevens Cyd Lacanienta Nancy Perrin Mark C. Edberg Thomas A. Mellman Yvonne Bronner Roger Clark Cheryl R. Dennison Himmelfarb Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults Journal of Clinical and Translational Science COVID-19 clinical trial participation African Americans/Blacks Latinos social determinants of health |
| title | Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults |
| title_full | Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults |
| title_fullStr | Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults |
| title_full_unstemmed | Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults |
| title_short | Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults |
| title_sort | predictors of willingness to participate in covid 19 clinical trials among black and latino adults |
| topic | COVID-19 clinical trial participation African Americans/Blacks Latinos social determinants of health |
| url | https://www.cambridge.org/core/product/identifier/S205986612400654X/type/journal_article |
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