Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions
Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association published guidelines recommending single high-dose weight-based gentamicin prophylaxis of 5 mg/kg for procedures involving urologic prostheses. These guidelines are based on the theoretical renal safety and i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2018/3479202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545703034880000 |
|---|---|
| author | Robert H. Moore Uzoma A. Anele Sarah C. Krzastek Adam P. Klausner J. Tyler Roseman |
| author_facet | Robert H. Moore Uzoma A. Anele Sarah C. Krzastek Adam P. Klausner J. Tyler Roseman |
| author_sort | Robert H. Moore |
| collection | DOAJ |
| description | Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association published guidelines recommending single high-dose weight-based gentamicin prophylaxis of 5 mg/kg for procedures involving urologic prostheses. These guidelines are based on the theoretical renal safety and improved antimicrobial activity of a single large dose of gentamicin. However, the risk of nephrotoxicity after weight-based gentamicin prophylaxis specifically in penile prosthetic surgery has never been established with evidence-based studies. This is of special concern in light of the known high rates of preexisting conditions in this specific population. Therefore, in order to expose potential safety issues, we present three cases of postoperative acute kidney injury following weight-based gentamicin prophylaxis after implantation of inflatable penile prostheses. |
| format | Article |
| id | doaj-art-2e5d89c22b1c47528744d4c36d025395 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-2e5d89c22b1c47528744d4c36d0253952025-02-03T07:24:50ZengWileyCase Reports in Urology2090-696X2090-69782018-01-01201810.1155/2018/34792023479202Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting ConditionsRobert H. Moore0Uzoma A. Anele1Sarah C. Krzastek2Adam P. Klausner3J. Tyler Roseman4Virginia Commonwealth University School of Medicine, 1201 E. Marshall Street, Richmond, VA 23298, USADivision of Urology, Virginia Commonwealth University Medical Center, West Hospital, 7th Floor, 1200 E. Broad Street, Richmond, VA 23298-0118, USADivision of Urology, Virginia Commonwealth University Medical Center, West Hospital, 7th Floor, 1200 E. Broad Street, Richmond, VA 23298-0118, USADivision of Urology, Virginia Commonwealth University Medical Center, West Hospital, 7th Floor, 1200 E. Broad Street, Richmond, VA 23298-0118, USADivision of Urology, Virginia Commonwealth University Medical Center, West Hospital, 7th Floor, 1200 E. Broad Street, Richmond, VA 23298-0118, USADespite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association published guidelines recommending single high-dose weight-based gentamicin prophylaxis of 5 mg/kg for procedures involving urologic prostheses. These guidelines are based on the theoretical renal safety and improved antimicrobial activity of a single large dose of gentamicin. However, the risk of nephrotoxicity after weight-based gentamicin prophylaxis specifically in penile prosthetic surgery has never been established with evidence-based studies. This is of special concern in light of the known high rates of preexisting conditions in this specific population. Therefore, in order to expose potential safety issues, we present three cases of postoperative acute kidney injury following weight-based gentamicin prophylaxis after implantation of inflatable penile prostheses.http://dx.doi.org/10.1155/2018/3479202 |
| spellingShingle | Robert H. Moore Uzoma A. Anele Sarah C. Krzastek Adam P. Klausner J. Tyler Roseman Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions Case Reports in Urology |
| title | Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions |
| title_full | Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions |
| title_fullStr | Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions |
| title_full_unstemmed | Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions |
| title_short | Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions |
| title_sort | report of three cases of aki following weight based gentamicin prophylaxis for ipp implantation potential concerns for patients with preexisting conditions |
| url | http://dx.doi.org/10.1155/2018/3479202 |
| work_keys_str_mv | AT roberthmoore reportofthreecasesofakifollowingweightbasedgentamicinprophylaxisforippimplantationpotentialconcernsforpatientswithpreexistingconditions AT uzomaaanele reportofthreecasesofakifollowingweightbasedgentamicinprophylaxisforippimplantationpotentialconcernsforpatientswithpreexistingconditions AT sarahckrzastek reportofthreecasesofakifollowingweightbasedgentamicinprophylaxisforippimplantationpotentialconcernsforpatientswithpreexistingconditions AT adampklausner reportofthreecasesofakifollowingweightbasedgentamicinprophylaxisforippimplantationpotentialconcernsforpatientswithpreexistingconditions AT jtylerroseman reportofthreecasesofakifollowingweightbasedgentamicinprophylaxisforippimplantationpotentialconcernsforpatientswithpreexistingconditions |