Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0005 |
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| author | Saracheva Kremena Hrischev Petar Vasileva Liliya Topolov Mariyan Nikolova Julia Getova Damianka |
| author_facet | Saracheva Kremena Hrischev Petar Vasileva Liliya Topolov Mariyan Nikolova Julia Getova Damianka |
| author_sort | Saracheva Kremena |
| collection | DOAJ |
| description | The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive “tail-cuff” method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety. |
| format | Article |
| id | doaj-art-2e3a0768909842278f3ff4d8a7bc59f0 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2e3a0768909842278f3ff4d8a7bc59f02025-02-02T11:49:57ZengSciendoActa Pharmaceutica1846-95582020-06-0170223924710.2478/acph-2020-0005acph-2020-0005Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female ratsSaracheva Kremena0Hrischev Petar1Vasileva Liliya2Topolov Mariyan3Nikolova Julia4Getova Damianka5Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University Plovdiv, Plovdiv, BulgariaDepartment of Physiology, Faculty of Medicine, Medical University Plovdiv, Plovdiv, BulgariaDepartment of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University Plovdiv, Plovdiv, BulgariaDepartment of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University Plovdiv, Plovdiv, BulgariaDepartment of Physiology, Faculty of Medicine, Medical University Plovdiv, Plovdiv, BulgariaLaboratory of Neuropharmacology, Technological Center of Emergency Medicine (TCEMED), Plovdiv, BulgariaThe introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive “tail-cuff” method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.https://doi.org/10.2478/acph-2020-0005almotriptanfrovatriptanratarterial pressure |
| spellingShingle | Saracheva Kremena Hrischev Petar Vasileva Liliya Topolov Mariyan Nikolova Julia Getova Damianka Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats Acta Pharmaceutica almotriptan frovatriptan rat arterial pressure |
| title | Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats |
| title_full | Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats |
| title_fullStr | Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats |
| title_full_unstemmed | Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats |
| title_short | Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats |
| title_sort | effects of new generation triptans frovatriptan and almotriptan on hemodynamic parameters in intact male and female rats |
| topic | almotriptan frovatriptan rat arterial pressure |
| url | https://doi.org/10.2478/acph-2020-0005 |
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