Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism
Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2022/4655249 |
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| author | Angela Vidal Carolin Dhakal |
| author_facet | Angela Vidal Carolin Dhakal |
| author_sort | Angela Vidal |
| collection | DOAJ |
| description | Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency. |
| format | Article |
| id | doaj-art-2e35dcd33bf34c00b30f300c3b58e8fb |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-2e35dcd33bf34c00b30f300c3b58e8fb2025-02-03T01:20:17ZengWileyCase Reports in Obstetrics and Gynecology2090-66922022-01-01202210.1155/2022/4655249Association of Beta-Thalassaemia and Hypogonadotropic HypogonadismAngela Vidal0Carolin Dhakal1Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyThalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.http://dx.doi.org/10.1155/2022/4655249 |
| spellingShingle | Angela Vidal Carolin Dhakal Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism Case Reports in Obstetrics and Gynecology |
| title | Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism |
| title_full | Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism |
| title_fullStr | Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism |
| title_full_unstemmed | Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism |
| title_short | Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism |
| title_sort | association of beta thalassaemia and hypogonadotropic hypogonadism |
| url | http://dx.doi.org/10.1155/2022/4655249 |
| work_keys_str_mv | AT angelavidal associationofbetathalassaemiaandhypogonadotropichypogonadism AT carolindhakal associationofbetathalassaemiaandhypogonadotropichypogonadism |