Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires
Background. Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2024/4435791 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553045590802432 |
|---|---|
| author | Georg Hoene Nikolaus von Hahn Denise Sievers Lukas Schuffelen Susanne Wolfer Kathi Goldstein Boris Schminke Phillipp Brockmeyer Philipp Kauffmann |
| author_facet | Georg Hoene Nikolaus von Hahn Denise Sievers Lukas Schuffelen Susanne Wolfer Kathi Goldstein Boris Schminke Phillipp Brockmeyer Philipp Kauffmann |
| author_sort | Georg Hoene |
| collection | DOAJ |
| description | Background. Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients with a history of antiresorptive or antiangiogenic agent use without radiation exposure to the head or neck. Patients and Materials and Methods. This prospective study over the period from May 2020 to December 2021 included a representative sample consisting of 27 patients with at least stage 2 MRONJ lesions who underwent surgical rehabilitation via oral and maxillofacial surgery at the University Medical Center Göttingen, Germany. Quality of life data were collected over a 6-month postoperative period using the Health-Related QOL (SF-12) and Oral Health-Related QOL (OHIP-14) questionnaires. Results. A total of 27 patients considered in the study had a total of 42 MRONJ lesions, corresponding to a mean of 1.56 necroses per patient. MRONJ lesions were downstaged in 85% of the patients. HRQOL was evaluated with the SF-12 questionnaire. Significant improvements were found in six of the eight categories (General Health (p <0.001), Bodily Pain (p<0.001), Mental Health (p<0.001), Vitality (p <0.001), Role-Emotional (p=0.028), and Social Functioning (p=0.031)). The OHRQOL score also improved significantly after surgical intervention (p<0.001). Conclusion. With completed surgical therapy, improvements in HRQOL and OHRQOL are measurable. |
| format | Article |
| id | doaj-art-2e2b2c5cc46c461e81a286aa2f96518d |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-2e2b2c5cc46c461e81a286aa2f96518d2025-02-03T05:56:54ZengWileyInternational Journal of Dentistry1687-87362024-01-01202410.1155/2024/4435791Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 QuestionnairesGeorg Hoene0Nikolaus von Hahn1Denise Sievers2Lukas Schuffelen3Susanne Wolfer4Kathi Goldstein5Boris Schminke6Phillipp Brockmeyer7Philipp Kauffmann8Clinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryPolyclinic for OrthodonticsClinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryClinic for Oral and Maxillofacial SurgeryBackground. Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients with a history of antiresorptive or antiangiogenic agent use without radiation exposure to the head or neck. Patients and Materials and Methods. This prospective study over the period from May 2020 to December 2021 included a representative sample consisting of 27 patients with at least stage 2 MRONJ lesions who underwent surgical rehabilitation via oral and maxillofacial surgery at the University Medical Center Göttingen, Germany. Quality of life data were collected over a 6-month postoperative period using the Health-Related QOL (SF-12) and Oral Health-Related QOL (OHIP-14) questionnaires. Results. A total of 27 patients considered in the study had a total of 42 MRONJ lesions, corresponding to a mean of 1.56 necroses per patient. MRONJ lesions were downstaged in 85% of the patients. HRQOL was evaluated with the SF-12 questionnaire. Significant improvements were found in six of the eight categories (General Health (p <0.001), Bodily Pain (p<0.001), Mental Health (p<0.001), Vitality (p <0.001), Role-Emotional (p=0.028), and Social Functioning (p=0.031)). The OHRQOL score also improved significantly after surgical intervention (p<0.001). Conclusion. With completed surgical therapy, improvements in HRQOL and OHRQOL are measurable.http://dx.doi.org/10.1155/2024/4435791 |
| spellingShingle | Georg Hoene Nikolaus von Hahn Denise Sievers Lukas Schuffelen Susanne Wolfer Kathi Goldstein Boris Schminke Phillipp Brockmeyer Philipp Kauffmann Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires International Journal of Dentistry |
| title | Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires |
| title_full | Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires |
| title_fullStr | Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires |
| title_full_unstemmed | Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires |
| title_short | Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires |
| title_sort | improvement of quality of life after surgical treatment of patients with mronj a prospective analysis using the sf 12 and ohip 14 questionnaires |
| url | http://dx.doi.org/10.1155/2024/4435791 |
| work_keys_str_mv | AT georghoene improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT nikolausvonhahn improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT denisesievers improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT lukasschuffelen improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT susannewolfer improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT kathigoldstein improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT borisschminke improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT phillippbrockmeyer improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires AT philippkauffmann improvementofqualityoflifeaftersurgicaltreatmentofpatientswithmronjaprospectiveanalysisusingthesf12andohip14questionnaires |