Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil
RAFT polymerization with cross-linking was used to prepare core cross-linked star polymers bearing temperature sensitive arms. The arms consisted of a diblock copolymer containing N-isopropylacrylamide (NIPAAm) and 4-methacryloyloxy benzoic acid (4MBA) in the temperature sensitive block and poly(hex...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/4543191 |
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| author | Elizabeth Sánchez-Bustos José M. Cornejo-Bravo Angel Licea-Claverie |
| author_facet | Elizabeth Sánchez-Bustos José M. Cornejo-Bravo Angel Licea-Claverie |
| author_sort | Elizabeth Sánchez-Bustos |
| collection | DOAJ |
| description | RAFT polymerization with cross-linking was used to prepare core cross-linked star polymers bearing temperature sensitive arms. The arms consisted of a diblock copolymer containing N-isopropylacrylamide (NIPAAm) and 4-methacryloyloxy benzoic acid (4MBA) in the temperature sensitive block and poly(hexyl acrylate) forming the second hydrophobic block, while ethyleneglycol dimethacrylate was used to form the core. The acid comonomer provides pH sensitivity to the arms and also increases the transition temperature of polyNIPAAm to values in the range of 40 to 46°C. Light scattering and atomic force microscopy studies suggest that loose core star polymers were obtained. The star polymers were loaded with 5-fluorouracil (5-FU), an anticancer agent, in values of up to 30 w/w%. In vitro release experiments were performed at different temperatures and pH values, as well as with heating and cooling temperature cycles. Faster drug release was obtained at 42°C or pH 6, compared to normal physiological conditions (37°C, pH 7.4). The drug carriers prepared acted as nanopumps changing the release kinetics of 5-FU when temperatures cycles were applied, in contrast with release rates at a constant temperature. The prepared core cross-linked star polymers represent advanced drug delivery vehicles optimized for 5-FU with potential application in cancer treatment. |
| format | Article |
| id | doaj-art-2e2aba82593f4b63aa69f34bc2298019 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-2e2aba82593f4b63aa69f34bc22980192025-02-03T05:58:28ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/45431914543191Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-FluorouracilElizabeth Sánchez-Bustos0José M. Cornejo-Bravo1Angel Licea-Claverie2Instituto Tecnológico de Tijuana, Centro de Graduados e Investigación en Química, Apartado Postal 1166, 22000 Tijuana, BC, MexicoFacultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, 22390 Tijuana, BC, MexicoInstituto Tecnológico de Tijuana, Centro de Graduados e Investigación en Química, Apartado Postal 1166, 22000 Tijuana, BC, MexicoRAFT polymerization with cross-linking was used to prepare core cross-linked star polymers bearing temperature sensitive arms. The arms consisted of a diblock copolymer containing N-isopropylacrylamide (NIPAAm) and 4-methacryloyloxy benzoic acid (4MBA) in the temperature sensitive block and poly(hexyl acrylate) forming the second hydrophobic block, while ethyleneglycol dimethacrylate was used to form the core. The acid comonomer provides pH sensitivity to the arms and also increases the transition temperature of polyNIPAAm to values in the range of 40 to 46°C. Light scattering and atomic force microscopy studies suggest that loose core star polymers were obtained. The star polymers were loaded with 5-fluorouracil (5-FU), an anticancer agent, in values of up to 30 w/w%. In vitro release experiments were performed at different temperatures and pH values, as well as with heating and cooling temperature cycles. Faster drug release was obtained at 42°C or pH 6, compared to normal physiological conditions (37°C, pH 7.4). The drug carriers prepared acted as nanopumps changing the release kinetics of 5-FU when temperatures cycles were applied, in contrast with release rates at a constant temperature. The prepared core cross-linked star polymers represent advanced drug delivery vehicles optimized for 5-FU with potential application in cancer treatment.http://dx.doi.org/10.1155/2016/4543191 |
| spellingShingle | Elizabeth Sánchez-Bustos José M. Cornejo-Bravo Angel Licea-Claverie Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil Journal of Chemistry |
| title | Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil |
| title_full | Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil |
| title_fullStr | Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil |
| title_full_unstemmed | Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil |
| title_short | Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil |
| title_sort | core cross linked star polymers for temperature ph controlled delivery of 5 fluorouracil |
| url | http://dx.doi.org/10.1155/2016/4543191 |
| work_keys_str_mv | AT elizabethsanchezbustos corecrosslinkedstarpolymersfortemperaturephcontrolleddeliveryof5fluorouracil AT josemcornejobravo corecrosslinkedstarpolymersfortemperaturephcontrolleddeliveryof5fluorouracil AT angelliceaclaverie corecrosslinkedstarpolymersfortemperaturephcontrolleddeliveryof5fluorouracil |