Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo

Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo

Abstract Objectives This study explored the potential of Zebularine (Zeb), a DNA methyltransferase inhibitor (DNMTi), and Valproic acid (Vpa), a histone deacetylase inhibitor (HDACi), as a combined treatment strategy for OSCC. Materials and methods OSCC cell lines, HSC4 (well-differentiated type) an...

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Main Authors: Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Fumiya Harada, Dedy Ariwansa, Sarita Giri, Jun Sato, Hiroki Nagayasu, Yoshihiro Abiko
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Epigenetics
Oral squamous cell carcinoma
Valproic acid
Zebularine
Online Access:https://doi.org/10.1007/s12672-025-02928-y
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