Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron
Abstract Background Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats. Methods Rats were divided into 6 groups including control, PP...
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2025-01-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | https://doi.org/10.1186/s12906-025-04750-z |
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| author | Mona M. Hashem Eman I. Hassanen Neven H. Hassan Marwa A. Ibrahim Marwa Y. Issa Mohamed A. Farag Sherif A. Hamdy |
| author_facet | Mona M. Hashem Eman I. Hassanen Neven H. Hassan Marwa A. Ibrahim Marwa Y. Issa Mohamed A. Farag Sherif A. Hamdy |
| author_sort | Mona M. Hashem |
| collection | DOAJ |
| description | Abstract Background Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats. Methods Rats were divided into 6 groups including control, PP-treated, HFM-exposed, and co-treated (HFM + PP) groups. Immune function, antioxidant activity, and organ damage were assessed. Furthermore, UPLC-MS/MS analysis identified potential bioactive compounds in PP extract. Results HFM exposure suppressed immune responses and caused organ damage. Notably, the co-administration of PP extract with HFM reversed these effects, indicating its ability to reduce oxidative stress and protect the immune system. UPLC-MS/MS analysis of PP calyces ethanolic extract revealed its richness in various health-promoting metabolites, including acyl sucrose sugar, withanolides, and flavonoids, which may provide valuable insight into the underlying mechanisms of PP’s calyces protective effects against HFM toxicity. Conclusions This study provides novel insights into the potential of P. peruviana L. calyces ethanolic extract as a natural agent to counteract the harmful effects of HFM exposure. These findings have significant implications for developing effective strategies to mitigate pesticide-induced toxicity and promote human health. |
| format | Article |
| id | doaj-art-2e22601bbd75437bb659e481efdd5376 |
| institution | Kabale University |
| issn | 2662-7671 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj-art-2e22601bbd75437bb659e481efdd53762025-01-26T12:15:11ZengBMCBMC Complementary Medicine and Therapies2662-76712025-01-0125111810.1186/s12906-025-04750-zPhysalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuronMona M. Hashem0Eman I. Hassanen1Neven H. Hassan2Marwa A. Ibrahim3Marwa Y. Issa4Mohamed A. Farag5Sherif A. Hamdy6Pharmacognosy Department, Faculty of Pharmacy, Cairo UniversityDepartment of Pathology, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Physiology, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo UniversityPharmacognosy Department, Faculty of Pharmacy, Cairo UniversityPharmacognosy Department, Faculty of Pharmacy, Cairo UniversityPharmacognosy Department, Faculty of Pharmacy, Cairo UniversityAbstract Background Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats. Methods Rats were divided into 6 groups including control, PP-treated, HFM-exposed, and co-treated (HFM + PP) groups. Immune function, antioxidant activity, and organ damage were assessed. Furthermore, UPLC-MS/MS analysis identified potential bioactive compounds in PP extract. Results HFM exposure suppressed immune responses and caused organ damage. Notably, the co-administration of PP extract with HFM reversed these effects, indicating its ability to reduce oxidative stress and protect the immune system. UPLC-MS/MS analysis of PP calyces ethanolic extract revealed its richness in various health-promoting metabolites, including acyl sucrose sugar, withanolides, and flavonoids, which may provide valuable insight into the underlying mechanisms of PP’s calyces protective effects against HFM toxicity. Conclusions This study provides novel insights into the potential of P. peruviana L. calyces ethanolic extract as a natural agent to counteract the harmful effects of HFM exposure. These findings have significant implications for developing effective strategies to mitigate pesticide-induced toxicity and promote human health.https://doi.org/10.1186/s12906-025-04750-zPhysalis peruvianaHexaflumuronImmune system toxicityOxidative stressAnti-inflammatoryUPLC-MS/MS analysis |
| spellingShingle | Mona M. Hashem Eman I. Hassanen Neven H. Hassan Marwa A. Ibrahim Marwa Y. Issa Mohamed A. Farag Sherif A. Hamdy Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron BMC Complementary Medicine and Therapies Physalis peruviana Hexaflumuron Immune system toxicity Oxidative stress Anti-inflammatory UPLC-MS/MS analysis |
| title | Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron |
| title_full | Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron |
| title_fullStr | Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron |
| title_full_unstemmed | Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron |
| title_short | Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron |
| title_sort | physalis peruviana calyces extract ameliorate oxidative stress inflammation and immune loss in rats exposed to hexaflumuron |
| topic | Physalis peruviana Hexaflumuron Immune system toxicity Oxidative stress Anti-inflammatory UPLC-MS/MS analysis |
| url | https://doi.org/10.1186/s12906-025-04750-z |
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