Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes
Depression is a common neurological disease that seriously affects human health. There are many hypotheses about the pathogenesis of depression, and the most widely recognized and applied is the monoamine hypothesis. However, no hypothesis can fully explain the pathogenesis of depression. At present...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8861903 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554553776537600 |
|---|---|
| author | Wenbo Xu Xiaoxiao Yao Fangyi Zhao Haisheng Zhao Ziqian Cheng Wei Yang Ranji Cui Songbai Xu Bingjin Li |
| author_facet | Wenbo Xu Xiaoxiao Yao Fangyi Zhao Haisheng Zhao Ziqian Cheng Wei Yang Ranji Cui Songbai Xu Bingjin Li |
| author_sort | Wenbo Xu |
| collection | DOAJ |
| description | Depression is a common neurological disease that seriously affects human health. There are many hypotheses about the pathogenesis of depression, and the most widely recognized and applied is the monoamine hypothesis. However, no hypothesis can fully explain the pathogenesis of depression. At present, the brain-derived neurotrophic factor (BDNF) and neurogenesis hypotheses have highlighted the important role of plasticity in depression. The plasticity of neurons and glial cells plays a vital role in the transmission and integration of signals in the central nervous system. Plasticity is the adaptive change in the nervous system in response to changes in external signals. The hippocampus is an important anatomical area associated with depression. Studies have shown that some antidepressants can treat depression by changing the plasticity of the hippocampus. Furthermore, caloric restriction has also been shown to affect antidepressant and hippocampal plasticity changes. In this review, we summarize the latest research, focusing on changes in the plasticity of hippocampal neurons and glial cells in depression and the role of BDNF in the changes in hippocampal plasticity in depression, as well as caloric restriction and mitochondrial plasticity. This review may contribute to the development of antidepressant drugs and elucidating the mechanism of depression. |
| format | Article |
| id | doaj-art-2e1a3fc875ed4d4588f5680fe812e0cc |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2e1a3fc875ed4d4588f5680fe812e0cc2025-02-03T05:51:11ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88619038861903Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These ChangesWenbo Xu0Xiaoxiao Yao1Fangyi Zhao2Haisheng Zhao3Ziqian Cheng4Wei Yang5Ranji Cui6Songbai Xu7Bingjin Li8Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaDepression is a common neurological disease that seriously affects human health. There are many hypotheses about the pathogenesis of depression, and the most widely recognized and applied is the monoamine hypothesis. However, no hypothesis can fully explain the pathogenesis of depression. At present, the brain-derived neurotrophic factor (BDNF) and neurogenesis hypotheses have highlighted the important role of plasticity in depression. The plasticity of neurons and glial cells plays a vital role in the transmission and integration of signals in the central nervous system. Plasticity is the adaptive change in the nervous system in response to changes in external signals. The hippocampus is an important anatomical area associated with depression. Studies have shown that some antidepressants can treat depression by changing the plasticity of the hippocampus. Furthermore, caloric restriction has also been shown to affect antidepressant and hippocampal plasticity changes. In this review, we summarize the latest research, focusing on changes in the plasticity of hippocampal neurons and glial cells in depression and the role of BDNF in the changes in hippocampal plasticity in depression, as well as caloric restriction and mitochondrial plasticity. This review may contribute to the development of antidepressant drugs and elucidating the mechanism of depression.http://dx.doi.org/10.1155/2020/8861903 |
| spellingShingle | Wenbo Xu Xiaoxiao Yao Fangyi Zhao Haisheng Zhao Ziqian Cheng Wei Yang Ranji Cui Songbai Xu Bingjin Li Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes Neural Plasticity |
| title | Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes |
| title_full | Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes |
| title_fullStr | Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes |
| title_full_unstemmed | Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes |
| title_short | Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes |
| title_sort | changes in hippocampal plasticity in depression and therapeutic approaches influencing these changes |
| url | http://dx.doi.org/10.1155/2020/8861903 |
| work_keys_str_mv | AT wenboxu changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT xiaoxiaoyao changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT fangyizhao changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT haishengzhao changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT ziqiancheng changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT weiyang changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT ranjicui changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT songbaixu changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges AT bingjinli changesinhippocampalplasticityindepressionandtherapeuticapproachesinfluencingthesechanges |